Evidence map›Paper›PMID 29334183›Full record

ReviewAdvanced healthcare materials2018

Engineering Polymersomes for Diagnostics and Therapy.

Jiayu Leong, Jye Yng Teo, Vinay K Aakalu, Yi Yan Yang, Hyunjoon Kong

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 132 citations in OpenAlex.

  1. Review
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  6. Photo-PISA DrivenACS sensors · 2025
    Article
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  8. Review
  9. Review
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  14. Drug delivery for age-related bone diseases: From therapeutic targets to common and emerging therapeutic strategies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Review
  15. Review
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  18. Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jiayu LeongDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Jye Yng TeoDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Vinay K AakaluIllinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Yi Yan YangInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.
Hyunjoon KongDepartment of Chemical and Biomolecular Engineering, Department of Bioengineering, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID 0000-0003-4680-2968
University of Illinois Urbana-Champaign · USInstitute of Bioengineering and Nanotechnology · SGUniversity of Illinois Chicago · US

Funding

Nanocells for vascular normalization therapiesR01HL109192 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2011 to 2015
$1.9M
Study of Accessory Lacrimal Gland and Precursor Cell BiologyK08EY024339 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AAKALU, VINAY · 2014 to 2018
$1.2M
Development of a Liposomal Nanostimulator to Improve Stem Cell-Based Revascularization TherapiesR21HL131469 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2016 to 2017
$428k
NEI NIH HHS K08 EY024339NHLBI NIH HHS R01 HL109192NHLBI NIH HHS R21 HL131469
6 · The paper itself

Abstract

Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self-assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests. As such, polymersomes are increasingly being studied as carriers of imaging probes and therapeutic drugs. Effective delivery of polymersomes necessitates careful design of polymersomes. Therefore, this review article discusses the design strategies of polymersomes developed for enhanced transport and efficacy of imaging probes and therapeutic drugs. In particular, the article focuses on overviewing technologies to regulate the size, structure, shape, surface activity, and stimuli- responsiveness of polymersomes and discussing the extent to which these properties and structure of polymersomes influence the efficacy of cargo molecules. Taken together with future considerations, this article will serve to improve the controllability of polymersome functions and accelerate the use of polymersomes in biomedical applications.

Indexed as

Drug CarriersNanoparticlesPolymersAnimalsHumansParticle SizePathology, MolecularDrug CarriersPolymersbilayer membranebiomedicaldrug deliveryself-assemblyvesicles

Identifiers

PMID29334183
PMCPMC6377267
OpenAlexW2782819019

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.