ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
The resting-state fMRI arterial signal predicts differential blood transit time through the brain.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 81 citations in OpenAlex.
- Global Signal Removal (GSR) as graph spatial filtering.bioRxiv : the preprint server for biology · 2026Article
- Associations between cerebral blood transit time, amyloid-β pathology and cognitive decline in non-demented older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences.NeuroImage · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Coupling of Low Frequency Hemodynamic Oscillations Between the Brain and Spinal Cord.Human brain mapping · 2025Article
- Improving delay and strength maps derived from resting-state fMRI using PCA-based denoising and group data from the HCP dataset.Computers in biology and medicine · 2025Article
- The functional overlap between respiration and global signal and its behavioral relevance.Communications biology · 2025Article
- Novel identifications of cerebral hemodynamics using BOLD fMRI in patients with sickle cell disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The link to steady-state oxidative metabolism and hemodynamics varies across rs-fMRI metrics: A whole-brain assessment using macrovascular correction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging.Interface focus · 2024Article
- Altered brain perfusion and oxygen levels relate to sleepiness and attention in post-COVID syndrome.Annals of clinical and translational neurology · 2024Article
- Brain-wide functional connectivity artifactually inflates throughout functional magnetic resonance imaging scans.Nature human behaviour · 2024Article
- Effects of clamping end-tidal CONMR in biomedicine · 2024Article
- Assessment of the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Reproducibility of cerebral perfusion measurements using BOLD delay.Human brain mapping · 2023Article
- Resting-state networks representation of the global phenomena.Frontiers in neuroscience · 2023Article
- Beyond noise to function: reframing the global brain activity and its dynamic topography.Communications biology · 2022Review
- Article
- Brain-wide ongoing activity is responsible for significant cross-trial BOLD variability.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A parsimonious description of global functional brain organization in three spatiotemporal patterns.Nature neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous studies have found that aperiodic, systemic low-frequency oscillations (sLFOs) are present in blood-oxygen-level-dependent (BOLD) data. These signals are in the same low frequency band as the "resting state" signal; however, they are distinct signals which represent non-neuronal, physiological oscillations. The same sLFOs are found in the periphery (i.e. finger tips) as changes in oxy/deoxy-hemoglobin concentration using concurrent near-infrared spectroscopy. Together, this evidence points toward an extra-cerebral origin of these sLFOs. If this is the case, it is expected that these sLFO signals would be found in the carotid arteries with time delays that precede the signals found in the brain. To test this hypothesis, we employed the publicly available MyConnectome dataset (a two-year longitudinal study of a single subject) to extract the sLFOs in the internal carotid arteries (ICAs) with the help of the T1/T2-weighted images. Significant, but negative, correlations were found between the LFO BOLD signals from the ICAs and (1) the global signal (GS), (2) the superior sagittal sinus, and (3) the jugulars. We found the consistent time delays between the sLFO signals from ICAs, GS and veins which coincide with the blood transit time through the cerebral vascular tree.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.