ArticleNeuroscience bulletin2018
Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies.
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In one paragraph
Article in Neuroscience bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- A Systemically Administered Humanized Anti-Nav1.7 Antibody with Long-Lasting Analgesic Activity and Preserved Physiological Nociception.Pharmaceutics · 2026Article
- Modulation of ion channels as emerging therapeutic targets in the treatment of diabetic neuropathy.EXCLI journal · 2026Review
- Possible Anti-Pain Vaccines: A Narrative Review of Emerging Strategies and Clinical Prospects.Vaccines · 2025Review
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Inhibition of NaRSC medicinal chemistry · 2022Review
- Article
- Voltage-gated sodium channels in diabetic sensory neuropathy: Function, modulation, and therapeutic potential.Frontiers in cellular neuroscience · 2022Review
- Nociceptor Overexpression of NaThe journal of pain · 2021Article
- CXCL10/CXCR3 Signaling in the DRG Exacerbates Neuropathic Pain in Mice.Neuroscience bulletin · 2021Article
- Bioresearch of New 1Molecules (Basel, Switzerland) · 2020Article
- The Specific Effects of OD-1, a Peptide Activator, on Voltage-Gated Sodium Current and Seizure Susceptibility.International journal of molecular sciences · 2020Article
- TASK-3: New Target for Pain-Relief.Neuroscience bulletin · 2020Article
- Taxane-induced neurotoxicity: Pathophysiology and therapeutic perspectives.British journal of pharmacology · 2020Review
- Tetrodotoxin-Sensitive Neuronal-Type NaJournal of the American Heart Association · 2020Article
- SCN9A Epileptic Encephalopathy Mutations Display a Gain-of-function Phenotype and Distinct Sensitivity to Oxcarbazepine.Neuroscience bulletin · 2020Article
- The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.British journal of pharmacology · 2020Article
- Antibodies and venom peptides: new modalities for ion channels.Nature reviews. Drug discovery · 2019Review
- GpTx-1 and [AlaBritish journal of pharmacology · 2018Article
- Modulation of sodium channels as pharmacological tool for pain therapy-highlights and gaps.Naunyn-Schmiedeberg's archives of pharmacology · 2018Review
- Recent Progress in Understanding the Mechanisms of Pain and Itch: the Second Special Issue.Neuroscience bulletin · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Sangsu BangDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.ORCID http://orcid.org/0000-0002-9092-0075
Jiho YooDepartment of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, NC, 27710, USA.
Xingrui GongPain Research Center, Department of Anesthesiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0531, USA.
Di LiuDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.
Qingjian HanDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.
Xin LuoDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.
Wonseok ChangDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.
Gang ChenDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.
Sang-Taek ImDepartment of Physiology, College of Medicine, Gachon University, Incheon, 21999, Korea.
Yong Ho KimDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA.
Judith A StrongPain Research Center, Department of Anesthesiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0531, USA.
Ma-Zhong ZhangDepartment of Anesthesiology, Shanghai Children's Medical Center, Shanghai, 200127, China.
Jun-Ming ZhangPain Research Center, Department of Anesthesiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267-0531, USA. jun-ming.zhang@uc.edu.
Seok-Yong LeeDepartment of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, NC, 27710, USA. seok-yong.lee@duke.edu.
Ru-Rong JiDepartment of Anesthesiology, Duke University Medical Center, 595 LaSalle St, Durham, NC, 27710, USA. ru-rong.ji@duke.edu.ORCID http://orcid.org/0000-0002-9355-3688
Duke Medical Center · USDuke University · USGachon University · KRSabin Vaccine Institute · USShanghai Children's Medical Center · CNEulji University · KR
Funding
STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTINGR01NS045594 · NINDS · UNIVERSITY OF CINCINNATI · PI ZHANG, JUN-MING · 2004 to 2025
$8.6MNEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAINR01NS055860 · NINDS · UNIVERSITY OF CINCINNATI · PI ZHANG, JUN-MING · 2008 to 2017
$3.7MDevelopment of novel therapeutics for pain and itch reliefR01NS089479 · NINDS · DUKE UNIVERSITY · PI JI, RU-RONG, LEE, SEOK-YONG · 2014 to 2017
$964kNINDS NIH HHS R01 NS045594NINDS NIH HHS R01 NS055860NINDS NIH HHS R01 NS089479
Abstract
The voltage-gated Na
Indexed as
AnimalsAntibodies, MonoclonalBiotinCells, CulturedDisease Models, AnimalFemaleGanglia, SpinalHEK293 CellsHumansHybridomasHyperalgesiaMaleMiceMice, Inbred C57BLNAV1.5 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelAntibodies, MonoclonalBiotinNAV1.5 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelRecombinant ProteinsSCN5A protein, humanScn9a protein, mouseAnimal modelsPatch clamping (electrophysiology)Primary afferent neuronSodium channels
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.