Evidence map›Paper›PMID 29333534›Full record

ArticleArchives of stem cell research2015

The Stagnant Adaptation of Defined and Xeno-Free Culture of iPSCs in Academia.

Joseph T Vecchi, Tetsuro Wakatsuki

Abstract read
In one paragraph

Article in Archives of stem cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph T VecchiInvivoSciences, Inc., USA.
Tetsuro WakatsukiInvivoSciences, Inc., USA.

Funding

THE EFFECTS OF MYOFIBROBLASTS ON ELECTROMECHANICAL FUNCTION OF MODEL HEART TISSUER01HL109505 · NHLBI · WASHINGTON UNIVERSITY · PI ELSON, ELLIOT L., GENIN, GUY M · 2012 to 2015
$2.0M
Engineered Tissue Based Phenotypic Screening of Mixture based LibrariesR43AG052220 · NIA · INVIVOSCIENCES, INC. · PI WAKATSUKI, TETSURO · 2015 to 2016
$759k
An Aging Heart Model for Drug DiscoveryR43AG054270 · NIA · INVIVOSCIENCES, INC. · PI WAKATSUKI, TETSURO · 2016 to 2018
$494k
NHLBI NIH HHS R01 HL109505NIA NIH HHS R43 AG052220NIA NIH HHS R43 AG054270
6 · The paper itself

Abstract

Pluripotent Stem Cells were originally derived and cultured using a feeder layer of cells. Movements have been undertaken to transition from this method to one more defined, high-throughput, and without xenogenic factors. Tremendous research has been done in this area and many products have been developed, however, based on our analysis of recent publications in stem cell related journals many in academia are still using older methods like a feeder layer. In this short communication, we discuss the feasibility of transitioning to defined, xeno-free methods, how a standardized method could improve the field and industry, and that a study bringing together multiple institutions comparing culture methods could be done to evaluate the efficacy of these new methods.

Indexed as

DefinedMediaStem cellsXeno-free

Identifiers

PMID29333534
PMCPMC5766037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.