Evidence map›Paper›PMID 29333487›Full record

ArticleeNeuro

Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome.

C James Howell, Michael P Sceniak, Min Lang, Wenceslas Krakowiecki, Fatimah E Abouelsoud, Saloni U Lad, Heping Yu, David M Katz

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Potentiation of the MNeurobiology of disease · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  8. Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. GJournal of neurophysiology · 2020
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

C James HowellDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Michael P SceniakDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Min LangDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0002-3895-5342
Wenceslas KrakowieckiDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Fatimah E AbouelsoudDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Saloni U LadDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0003-2073-4311
Heping YuDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
David M KatzDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
University School · US

Funding

Prefrontal cortical dysfunction in Rett syndromeR56NS057398 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KATZ, DAVID M. · 2016 to 2016
$396k
Cortical mechanisms of cognitive dysfunction in Mecp2 Mutant MiceF31NS098574 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI HOWELL, CODY JAMES · 2016 to 2017
$64k
NINDS NIH HHS F31 NS098574NINDS NIH HHS R56 NS057398
6 · The paper itself

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2; Amir et al., 1999), a transcriptional regulatory protein (Klose et al., 2005). Mouse models of RTT (

Indexed as

RespirationAnimalsAuditory PerceptionCognitionConditioning, PsychologicalDesigner DrugsDisease Models, AnimalFearFemaleGenetic VectorsMethyl-CpG-Binding Protein 2Mice, 129 StrainMice, Inbred BALB CMice, TransgenicPrefrontal CortexPyramidal CellsDesigner DrugsMecp2 protein, mouseMethyl-CpG-Binding Protein 2Receptors, Cell Surfaceautism spectrum disorderDREADDhypofrontalityMecp2memorymPFC

Identifiers

PMID29333487
PMCPMC5762598
OpenAlexW2776221434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.