Evidence map›Paper›PMID 29333434›Full record

ArticleNuclear receptor research2017

CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT.

Shari Bodofsky, Francine Koitz, Bruce Wightman

Open access · diamondAbstract read
In one paragraph

Article in Nuclear receptor research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Mapping molluscan endocrinology: a systematic and critical appraisal.Biological reviews of the Cambridge Philosophical Society · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Transcriptional control of energy metabolism by nuclear receptors.Nature reviews. Molecular cell biology · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shari BodofskyBiology Department, Muhlenberg College, 2400 Chew St., Allentown, PA 18104.
Francine KoitzBiology Department, Muhlenberg College, 2400 Chew St., Allentown, PA 18104.
Bruce WightmanBiology Department, Muhlenberg College, 2400 Chew St., Allentown, PA 18104.
Muhlenberg College · US

Funding

Transcriptional Regulation of Cell Differentiation in C. elegans by TaillessR15GM107799 · NIGMS · MUHLENBERG COLLEGE · PI WIGHTMAN, BRUCE · 2014 to 2014
$286k
NIGMS NIH HHS R15 GM107799
6 · The paper itself

Abstract

The nuclear receptor gene family includes 18 members that are broadly conserved among multiple disparate animal phyla, indicating that they trace their evolutionary origins to the time at which animal life arose. Typical nuclear receptors contain two major domains: a DNA-binding domain and a C-terminal domain that may bind a lipophilic hormone. Many of these nuclear receptors play varied roles in animal development, including coordination of life cycle events and cellular differentiation. The well-studied genetic model systems of

Indexed as

C. elegansdevelopmentDrosophilaexaptationfunctional conservationmouse

Identifiers

PMID29333434
PMCPMC5761748
OpenAlexW2763409495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.