Evidence map›Paper›PMID 29333363›Full record

ArticleTranslational science of rare diseases2017

Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

Katherine Cheng, Sandeep K Gupta, Susanna Kantor, Jonathan T Kuhl, Seema S Aceves, Peter A Bonis, Kelley E Capocelli, Christina Carpenter, Mirna Chehade, Margaret H Collins and 15 more

Open access · bronzeAbstract read
In one paragraph

Article in Translational science of rare diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
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  5. Article
  6. Scientific journey to the first FDA-approved drug for eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
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  14. Emerging therapies for eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2020
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 2 countries.

Katherine ChengDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Sandeep K GuptaDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, University of Illinois College of Medicine, Peoria, IL, USA.
Susanna KantorDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Denver, CO, USA.
Jonathan T KuhlDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Seema S AcevesDivision of Allergy and Immunology, Department of Pediatrics and Medicine, University of California San Diego, CA, USA.
Peter A BonisDivision of Gastroenterology, Tufts Medical Center, Boston, MA, USA.
Kelley E CapocelliDepartment of Pathology, Children's Hospital Colorado, Denver, CO, USA.
Christina CarpenterHealth Informatics Institute, Rare Diseases Clinical Research Network, Tampa, FL, USA.
Mirna ChehadeMount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Margaret H CollinsDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Evan S DellonDepartment of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Gary W FalkDivision of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rashmi Gopal-SrivastavaOffice of Rare Diseases Research, National Center for Advancing Translational Sciences, National Institute of Health, Bethesda, MD, USA.
Nirmala GonsalvesDivision of Gastroenterology & Hepatology, Northwestern University The Feinberg School of Medicine, Chicago, IL, USA.
Ikuo HiranoDivision of Gastroenterology and Hepatology, Northwestern Medicine The Feinberg School of Medicine, Chicago, IL, USA.
Eileen C KingDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
John LeungDepartment of Gastroenterology, Tufts Medical Center, Boston, MA, USA.
Jeffrey P KrischerDepartments of Pediatrics and Medicine, Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Vincent A MukkadaDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Alain SchoepferDepartment of Gastroenterology and Hepatology, University Hospital Lausanne/CHUV, Lausanne, Switzerland.
Jonathan M SpergelDepartment of Allergy and Immunology, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA.
Alex StraumannDepartment of Gastroenterology and hepatology, University Hospital Zuerich, Switzerland.
Guang-Yu YangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Glenn T FurutaGastrointestinal Eosinophilic Diseases Program, Children's Hospital Colorado, Aurora, CO, USA.
Marc E RothenbergDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USChildren's Hospital Colorado · USNorthwestern University · USTufts Medical Center · USChildren's Hospital of Philadelphia · USIcahn School of Medicine at Mount Sinai · USIllinois College · USIndiana University School of MedicineNational Center for Advancing Translational Sciences · USNorthwestern Medicine · USResearch Network (United States) · USUniversity Hospital of Lausanne · CHUniversity of California San Diego · USUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of South Florida · US

Funding

Rare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1M
TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI GLENN T FURUTA, Marc E. Rothenberg · 2014 to 2026
$18.5M
NCATS NIH HHS U01 TR001263NIAID NIH HHS U54 AI117804
6 · The paper itself

Abstract

Eosinophilic gastrointestinal disorders (EGIDs) affect various segments of the gastrointestinal tract. Since these disorders are rare, collaboration is essential to enroll subjects in clinical studies and study the broader population. The Rare Diseases Clinical Research Network (RDCRN), a program of the National Center for Advancing Translational Sciences (NCATS), funded the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) in 2014 to advance the field of EGIDs. CEGIR facilitates collaboration among various centers, subspecialties, patients, professional organizations and patient-advocacy groups and includes 14 clinical sites. It has successfully initiated two large multi-center clinical studies looking to refine EGID diagnoses and management. Several pilot studies are underway that focus on various aspects of EGIDs including novel therapeutic interventions, diagnostic and monitoring methods, and the role of the microbiome in pathogenesis. CEGIR currently nurtures five physician-scholars through a career training development program and has published more than 40 manuscripts since its inception. This review focuses on CEGIR's operating model and progress and how it facilitates a framework for exchange of ideas and stimulates research and innovation. This consortium provides a model for progress on other potential clinical areas.

Indexed as

collaborationsEosinophilic diseasesmulticenter consortiumrare diseases

Identifiers

PMID29333363
PMCPMC5757645
OpenAlexW2761417437

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.