Evidence map›Paper›PMID 29333326›Full record

ArticleJournal of periodontal & implant science2017

Evaluation of the periodontal regenerative properties of patterned human periodontal ligament stem cell sheets.

Joong-Hyun Kim, Seok-Yeong Ko, Justin Ho Lee, Deok-Ho Kim, Jeong-Ho Yun

Abstract read
In one paragraph

Article in Journal of periodontal & implant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joong-Hyun KimDepartment of Periodontology, Chonbuk National University School of Dentistry and Institute of Oral Bioscience, Jeonju, Korea.ORCID https://orcid.org/0000-0002-2219-2264
Seok-Yeong KoDepartment of Periodontology, Chonbuk National University School of Dentistry and Institute of Oral Bioscience, Jeonju, Korea.ORCID https://orcid.org/0000-0002-0800-1409
Justin Ho LeeDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-0284-2389
Deok-Ho KimDepartment of Bioengineering, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-6989-6074
Jeong-Ho YunDepartment of Periodontology, Chonbuk National University School of Dentistry and Institute of Oral Bioscience, Jeonju, Korea.ORCID https://orcid.org/0000-0003-3929-4467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to determine the effects of patterned human periodontal ligament stem cell (hPDLSC) sheets fabricated using a thermoresponsive substratum.

methodsIn this study, we fabricated patterned hPDLSC sheets using nanotopographical cues to modulate the alignment of the cell sheet.

resultsThe hPDLSCs showed rapid monolayer formation on various surface pattern widths. Compared to cell sheets grown on flat surfaces, there were no significant differences in cell attachment and growth on the nanopatterned substratum. However, the patterned hPDLSC sheets showed higher periodontal ligamentogenesis-related gene expression in early stages than the unpatterned cell sheets.

conclusionsThis experiment confirmed that patterned cell sheets provide flexibility in designing hPDLSC sheets, and that these stem cell sheets may be candidates for application in periodontal regenerative therapy.

Indexed as

Extracellular matrixPeriodontal ligamentRegenerationStem cellsTissue engineering

Identifiers

PMID29333326
PMCPMC5764766

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.