Evidence map›Paper›PMID 29333258›Full record

ReviewF1000Research2017

An RNA decay factor wears a new coat: UPF3B modulates translation termination.

Zhaofeng Gao, Miles Wilkinson

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in F1000Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zhaofeng GaoDepartment of Reproductive Medicine, University of California San Diego Medical Center, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-6960-465X
Miles WilkinsonDepartment of Reproductive Medicine, University of California San Diego Medical Center, La Jolla, CA, USA.
University of California San Diego · US

Funding

The Role of NMD in Olfactory NeurogenesisR01GM111838 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WILKINSON, MILES FROME · 2014 to 2017
$1.6M
NIGMS NIH HHS R01 GM111838
6 · The paper itself

Abstract

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that has been subject to intense scrutiny. NMD identifies and degrades subsets of normal RNAs, as well as abnormal mRNAs containing premature termination codons. A core factor in this pathway-UPF3B-is an adaptor protein that serves as an NMD amplifier and an NMD branch-specific factor. UPF3B is encoded by an X-linked gene that when mutated causes intellectual disability and is associated with neurodevelopmental disorders, including schizophrenia and autism. Neu-Yilik

Indexed as

Nonsense-mediated RNA decayRNAtranslation terminationUPF3B

Identifiers

PMID29333258
PMCPMC5749124
OpenAlexW2778161995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.