Evidence map›Paper›PMID 29333196›Full record

ArticleResearch in autism spectrum disorders2017

Brief report: Reduced anxiety following Pivotal Response Treatment in young children with Autism Spectrum Disorder.

Jiedi Lei, Denis G Sukhodolsky, Sebiha M Abdullahi, Megan L Braconnier, Pamela Ventola

Open access · greenAbstract read
In one paragraph

Article in Research in autism spectrum disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiedi LeiYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT 06520-7900, USA.
Denis G SukhodolskyYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT 06520-7900, USA.
Sebiha M AbdullahiYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT 06520-7900, USA.
Megan L BraconnierYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT 06520-7900, USA.
Pamela VentolaYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT 06520-7900, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Subnetwork-based Quantitative Imaging Biomarkers for Therapy Assessment in AutismR01NS035193 · NINDS · YALE UNIVERSITY · PI JAMES S DUNCAN, LAWRENCE H. STAIB · 1996 to 2026
$9.2M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH100028NINDS NIH HHS R01 NS035193
6 · The paper itself

Abstract

Up to 40% of children with Autism Spectrum Disorder (ASD) exhibit co-occurring anxiety symptoms. Despite recent success in mitigating anxiety symptoms in school-aged children with ASD (mean age >9 years) using adapted versions of Cognitive Behavioural Therapy, little is known about potential treatment outcomes for younger children. To address the gap in the literature, this open-label study evaluated change in anxiety following a 16-week open-label trial of Pivotal Response Treatment (PRT) in children with ASD aged 4-8 years. PRT is a behavioural treatment based on the principles of Applied Behaviour Analysis and has a primary aim of increasing social communication skills in children with ASD through natural reinforcements. To minimise conflation of anxiety and other co-occurring symptoms such as disruptive behaviour and attention-deficit hyperactivity disorder, we measured anxiety using the autism anxiety subscale of the Child and Adolescent Symptom Inventory (CASI) devised by Sukhodolsky et al. (2008). We observed significant anxiety reduction over 16-weeks of PRT. Furthermore, anxiety reduction was independent of changes in autism symptom severity. This study shows promising results for PRT as an intervention for reducing anxiety in young children with ASD.

Indexed as

anxietyAutism Spectrum Disorder (ASD)Pivotal Response Treatment (PRT)

Identifiers

PMID29333196
PMCPMC5761743
OpenAlexW2754789514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.