ArticlePharmacognosy research2017
Autonomic Receptors and Nitric-Oxide Involvements in Mediating Vasorelaxation Effect Induced by
Article in Pharmacognosy research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors at 1 institution in 1 country.
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Abstract
context
aimsThis study aimed to investigate their vasorelaxation potential and the possible involvement of autonomic receptors and nitric oxide in mediating their effect. SETTINGS AND
designBoth extracts will be tested on isolated thoracic aorta rings of WKY and SHR. The involvement of autonomic receptors and nitric oxide will be elucidated using respective blockers. MATERIALS AND
methodsIsolated thoracic aorta rings from WKY and SHR were mounted onto myograph chambers to measure changes in the aorta tension. Increasing concentrations of AESP and MESP, from 1 μg/ml to 10 mg/ml were added onto the myograph chambers. Blockers such as atropine (1 μM), phentolamine (1 μM), propranolol (1 μM), and Nω-nitro-l-arginine methyl ester (100 μM) were preincubated before addition of extracts to check for involvement of muscarinic, α- and β-adrenergic receptors (AR) as well as nitric oxide, respectively. STATISTICAL ANALYSIS USED: Two-way ANOVA, followed by
resultsAESP and MESP caused significant vasorelaxations through nitric oxide pathway. The former was mediated through α-AR while the latter was mediated by β-adrenergic and muscarinic receptors.
conclusionVasorelaxation effect by AESP and MESP involved nitric oxide pathway which is possibly mediated by the autonomic receptors. SUMMARY: This is the first study that reveals significant vasorelaxation effect induced by
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