ReviewThe Clinical biochemist. Reviews2017
Clinical Utility and Measurement of Procalcitonin.
Review in The Clinical biochemist. Reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 6 syntheses or guidelines pooled it, 216 citations in OpenAlex.
- A genome- and phenome-wide association study of plasma procalcitonin concentrations in individuals of European ancestry.EBioMedicine · 2026Pooled it
- Procalcitonin and presepsin for detecting bacterial infection and spontaneous bacterial peritonitis in cirrhosis: A systematic review and meta-analysis.World journal of gastroenterology · 2025Pooled it
- Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines.World journal of emergency surgery : WJES · 2022Guideline
- Procalcitonin as a Candidate Biomarker for Malarial Infection and Severe Malaria: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Pooled it
- Procalcitonin as a predictive marker in COVID-19: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Application of a Prediction Model Based on the Laboratory Index Score in Prelabor Rupture of Membranes with Histologic Chorioamnionitis During Late Pregnancy.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Blood biomarkers and penalized logistic regression for the prediction of complicated appendicitis in children: a retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Development and temporal validation of a clinical prediction model to identify bacterial infection in hospitalised patients with systemic lupus erythematosus.Lupus science & medicine · 2026Article
- Procalcitonin as a predictor of length of stay in patients with odontogenic infections.Oral and maxillofacial surgery · 2026Article
- Procalcitonin kinetics in critically ill patients: a retrospective analysis of the impact of renal dysfunction and renal replacement therapy.Journal of anesthesia, analgesia and critical care · 2026Article
- To explore or not: machine learning models for intraoperative decision on testicular exploration in infants under 3 months with incarcerated inguinal hernia.BMC surgery · 2026Article
- Elevated procalcitonin levels in febrile children with exanthema subitum undergoing clinically indicated PCT testing: a retrospective cohort study.BMC infectious diseases · 2026Article
- Establishment of a Charlson comorbidity index-based model for predicting the preterm premature rupture of the membrane.Translational pediatrics · 2026Article
- Impact of Procalcitonin Kinetics on Mortality in Intensive Care Patients with Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- A Practical Guide to the Roles of Procalcitonin Measurement in Patients with Acute Pancreatitis.Journal of clinical medicine · 2026Review
- Perioperative Blood Biomarkers of Infectious and Non-Infectious Postoperative Pulmonary Complications: A Narrative Review.Journal of clinical medicine · 2026Review
- Prospective Evaluation of Blood-based and Microbiological Early Indicators of In-hospital Infectious Complications After Open Cystectomy.European urology open science · 2026Article
- Identifying the thresholds of C-reactive protein, procalcitonin, and interleukin-6 among children ≤36 months' old with fever without source at risk of serious bacterial infections: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Retrospective Analysis of Inflammatory Biomarker Patterns and Platelet Dynamics in Hospitalized Adults.International journal of general medicine · 2026Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Procalcitonin (PCT), regarded as a biomarker specific for bacterial infections, is used in a variety of clinical settings including primary care, emergency department and intensive care. PCT measurement aids in the diagnosis of sepsis and to guide and monitor antibiotic therapy. This article gives a brief overview of PCT and its use in guiding antibiotic therapy in various clinical settings, as well as its limitations. PCT performance in comparison with other biomarkers of infection in particular CRP is also reviewed. Owing to its greater availability, CRP has been widely used as a biomarker of infection and sepsis. PCT is often reported to be more superior to CRP, being more specific for sepsis and bacterial infection. PCT starts to rise earlier and returns to normal concentration more rapidly than CRP, allowing for an earlier diagnosis and better monitoring of disease progression.
Identifiers
29332972PMC5759088W2949821028What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.