Evidence map›Paper›PMID 29332450›Full record

ArticleTechnology in cancer research & treatment2017

Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.

Sheng Zhao, Gang Su, Wenke Yang, Ping Yue, Bing Bai, Yanyan Lin, Jinduo Zhang, Yongjiang Ba, Zhiwen Luo, Xiaoming Liu and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Sheng Zhao1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Gang Su5 Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Wenke Yang5 Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Ping Yue1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Bing Bai1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Yanyan Lin1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Jinduo Zhang1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Yongjiang Ba1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Zhiwen Luo1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Xiaoming Liu4 Department of General Surgery, Petrochemical General Hospital of Lanzhou, Lanzhou, Gansu, China.
Lili Zhao6 The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Yi Xie6 The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Yaowei Xu6 The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Shuo Li1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Wenbo Meng1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Xiaodong Xie5 Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
Xun Li1 Special Minimally Invasive Surgery, The First Clinical Medical College of Lanzhou University, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
First Hospital of Lanzhou University · CNLanzhou University · CNLanzhou University Second Hospital · CNLanzhou Petrochemical Polytechnic · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histological differentiation is a major pathological criterion indicating the risk of tumor invasion and metastasis in patients with hepatocellular carcinoma. The degree of tumor differentiation is controlled by a complex interacting network of associated proteins. The principal aim of the present study is to identify the possible differentiation-related proteins which may be used for early diagnosis and more effective therapies. We compared poorly differentiated and well-differentiated hepatocellular carcinoma tissues by using 2-dimensional gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Among the 11 identified protein spots, 6 were found to be upregulated in poorly differentiated hepatocellular carcinoma tissues and 5 were correspondingly downregulated. Immunohistochemistry was performed on 106 hepatocellular carcinoma tissues to confirm the results of the proteomic analysis. By using bioinformatic tools GO and STRING, these proteins were found to be related to catalytic activity, binding, and antioxidant activity. In particular, our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein β-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers.

Indexed as

AdultAgedAnnexin A2Biomarkers, TumorCarcinoma, HepatocellularCell DifferentiationFemaleGene Expression Regulation, NeoplasticHSP27 Heat-Shock ProteinsHumansLiver NeoplasmsMaleMiddle AgedNeoplasm InvasivenessNeoplasm MetastasisPeroxiredoxinsAnnexin A2ANXA2 protein, humanBiomarkers, TumorHSP27 Heat-Shock ProteinsPeroxiredoxinsPRDX2 protein, humanProteomebioinformationbiomarkersdifferentiationHCCimmunohistochemistryproteomics

Identifiers

PMID29332450
PMCPMC5762076
OpenAlexW2760048072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.