ArticleEnvironmental science and pollution research international2018
Comparative study of selenium and selenium nanoparticles with reference to acute toxicity, biochemical attributes, and histopathological response in fish.
Article in Environmental science and pollution research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 127 citations in OpenAlex.
- Surface-Engineered Selenium Nanozymes for Food Safety: Photoregulated Catalysis, Multimodal Antibacterial Mechanisms, and Emerging Applications in Food Processing, Packaging, and Biosensing.Comprehensive reviews in food science and food safety · 2026Review
- Bioremediation and optimization of selenate reduction by a novel Bacillus cabrialesii strain (Se1) producing red selenium nanoparticles with potential antibacterial activity.BMC microbiology · 2025Article
- Tailored Synthesis and Profiling of Capped Silver and Selenium Nanoparticles for Topical Applications in Paediatric Dentistry.Dentistry journal · 2025Article
- Comparative toxicity of zinc oxide nanoparticles and zinc salts in male mice: Hematological, biochemical, and histopathological impacts.Toxicology reports · 2025Article
- Evaluation of toxic effects of benzophenone on histopathology ofToxicology reports · 2025Article
- Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromis niloticus).BMC veterinary research · 2025Article
- Nano Selenium: A Promising Solution for Infectious Diseases - Current Status and Future Prospects.Current pharmaceutical design · 2025Review
- Dose-dependent hemato-biochemical and genotoxic responses of common carp (Frontiers in physiology · 2025Article
- Biosynthesis of selenium nanoparticles as a potential therapeutic agent in breast cancer: G2/M arrest and apoptosis induction.Toxicology reports · 2024Article
- The beneficial and toxic effects of selenium on zebrafish. A systematic review of the literature.Toxicology research · 2024Review
- Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies.Molecules (Basel, Switzerland) · 2024Review
- Manganese nutrient mitigates ammonia, arsenic toxicity and high temperature stress using gene regulation via NFkB mechanism in fish.Scientific reports · 2024Article
- Impact of Sel-PlexOpen veterinary journal · 2024Article
- Nano-copper Enhances Gene Regulation of Non-specific Immunity and Antioxidative Status of Fish Reared Under Multiple Stresses.Biological trace element research · 2023Article
- Multi biomarker approach to assess manganese and manganese nanoparticles toxicity in Pangasianodon hypophthalmus.Scientific reports · 2023Article
- Physiological Benefits of Novel Selenium Delivery via Nanoparticles.International journal of molecular sciences · 2023Review
- Health risk assessment and metal contamination in fish, water and soil sediments in the East Kolkata Wetlands, India, Ramsar site.Scientific reports · 2023Article
- Effects of Different Dietary Selenium Sources on the Meat Quality and Antioxidant Capacity of Yellow Catfish (Aquaculture nutrition · 2023Article
- Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer,Frontiers in pharmacology · 2023Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies have demonstrated that selenium (Se) and selenium nanoparticles (Se-NPs) exhibited toxicity at a higher concentration. The lethal concentration of Se and Se-NPs was estimated as 5.29 and 3.97 mg/L at 96 h in Pangasius hypophthalmus. However, the effect of different definite concentration of Se (4.5, 5.0, 5.5, and 6.0 mg/L) and Se-NPs (2.5, 3.0, 3.5, and 4.0 mg/L) was decided for acute experiment. Selenium and Se-NPs alter the biochemical attributes such as anti-oxidative status [catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities], neurotransmitter enzyme, cellular metabolic enzymes, stress marker, and histopathology of P. hypophthalmus in a dose- and time-dependent manner. CAT, SOD, and GST were significantly elevated (p < 0.01) when exposed to Se and Se-NPs, and similarly, a neurotransmitter enzyme (acetylcholine esterase (AChE)) was significantly inhibited in a time- and dose-dependent manner. Further, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and malate hydrogenase were noticeably (p < 0.01) affected by Se and Se-NPs from higher concentration to lower concentration. Stress markers such as cortisol and HSP 70 were drastically enhanced by exposure to Se and Se-NPs. All the cellular metabolic and stress marker parameters were elevated which might be due to hyperaccumulation of Se and Se-NPs in the vital organ and target tissues. The histopathology of liver and gill was also altered such as large vacuole, cloudy swelling, focal necrosis, interstitial edema, necrosis in liver, and thickening of primary lamellae epithelium and curling of secondary lamellae due to Se and Se-NP exposure. The study suggested that essential trace element in both forms (inorganic and nano) at higher concentration in acute exposure of Se and Se-NPs led to pronounced deleterious alteration on histopathology and cellular and metabolic activities of P. hypophthalmus.
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