Evidence map›Paper›PMID 29332262›Full record

ArticleJournal of cancer research and clinical oncology2018

Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor.

Gabrielle Karpinsky, Malgorzata A Krawczyk, Ewa Izycka-Swieszewska, Aleksandra Fatyga, Agnieszka Budka, Walentyna Balwierz, Grazyna Sobol, Beata Zalewska-Szewczyk, Magdalena Rychlowska-Pruszynska, Teresa Klepacka and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. The Microenvironment of Tongue Cancer.Advances in experimental medicine and biology · 2020
    Review
  6. Peripheral nerve injuries in the pediatric population: a review of the literature. Part III: peripheral nerve tumors in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019
    Review
  7. Article
  8. Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review.Computational and structural biotechnology journal · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Gabrielle KarpinskyChildren's Hospital of Michigan, 3901 Beaubien St, Detroit, MI, USA.
Malgorzata A KrawczykDepartment of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 7 Debinki Street, 80-211, Gdansk, Poland.
Ewa Izycka-SwieszewskaDepartment of Pathology and Neuropathology, Medical University of Gdansk, 1 Debinki Street, Gdansk, Poland.
Aleksandra FatygaDepartment of Pediatrics, Hematology and Oncology, University Clinical Centre, 7 Debinki Street, Gdansk, Poland.
Agnieszka BudkaDepartment of Pediatrics, Hematology and Oncology, University Clinical Centre, 7 Debinki Street, Gdansk, Poland.
Walentyna BalwierzDepartment of Pediatric Oncology and Hematology, Jagiellonian University Medical College, 265 Wielicka Street, Krakow, Poland.
Grazyna SobolDepartment of Pediatrics, Medical University of Silesia, 15 Medykow Street, Katowice, Poland.
Beata Zalewska-SzewczykDepartment of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, 36/50 Sporna Street, Lodz, Poland.
Magdalena Rychlowska-PruszynskaDepartment of Surgical Oncology, Institute of Mother and Child, 17A Kasprzaka Street, Warsaw, Poland.
Teresa KlepackaDepartment of Pathology, Institute of Mother and Child, 17A Kasprzaka Street, Warsaw, Poland.
Bozenna Dembowska-BaginskaDepartment of Oncology, Children's Memorial Health Institute, 20 Dzieci Polskich Street, Warsaw, Poland.
Bernarda KazanowskaDepartment of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, 213 Borowska Street, Wroclaw, Poland.
Anna GabrychDepartment of Pediatrics, Hematology and Oncology, University Clinical Centre, 7 Debinki Street, Gdansk, Poland.
Ewa BienDepartment of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 7 Debinki Street, 80-211, Gdansk, Poland. ebien@gumed.edu.pl.ORCID http://orcid.org/0000-0002-2091-2686
Gdańsk Medical University · PLUniversity Clinical Centre · PLChildren's Hospital of Michigan · USChildren's Memorial Health Institute · PLJagiellonian University · PLMedical University of Lodz · PLMedical University of Silesia · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSelected cell-cycle regulators and extracellular matrix proteins were found to play roles in malignant peripheral nerve sheath tumor (MPNST) biology. We aimed to analyze whether initial tumor tissue expressions of survivin, p53, cyclin D1, osteopontin (OPN) and fibronectin (FN) correlate with the response to neo-adjuvant CHT (naCHT) in children with advanced inoperable MPNST.

methodsThe study included 26 children with MPNST (M/F 14/12, median age 130 months) treated in Polish centers of pediatric oncology between 1992 and 2013. Tissue expression of markers was studied immunohistochemically in the manually performed tissue microarrays and assessed semi-quantitatively as low and high, based on the rate of positive cells and staining intensity.

resultsGood response to naCHT was noted in 47.6%, while poor-in 52.4% of patients. The response to naCHT was influenced negatively by the presence of neurofibromatosis NF1 and high initial tumor tissue expression of OPN, survivin, p53 and cyclin D1. Patients with high tumor expression of either OPN, survivin or p53 and those with simultaneous high expression of ≥ 3 of the markers, responded significantly worse to naCHT, than patients, in whom expression of ≤ 2 markers were detected at diagnosis. Nearly, 85% of patients expressing ≥ 3 markers, responded poor to CHT; while 87.5% of children, expressing ≤ 2 markers, were good responders.

conclusionThe initial tumor tissue expression of OPN, survivin, p53 and cyclin D1 may serve as markers to predict response to naCHT in pediatric advanced MPNST. Future studies in more numerous group of patients are needed to confirm these preliminary results.

Indexed as

AdolescentAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, PharmacologicalBiomarkers, TumorChildChild, PreschoolCyclin D1CytokinesDisease ProgressionFemaleFibronectinsHumansInfantInhibitor of Apoptosis ProteinsMaleNeoadjuvant TherapyBiomarkers, PharmacologicalBiomarkers, TumorBIRC5 protein, humanCCND1 protein, humanCyclin D1CytokinesFibronectinsFN1 protein, humanInhibitor of Apoptosis ProteinsOsteopontinSPP1 protein, humanSurvivinChildrenCyclin D1Malignant peripheral nerve sheath tumorOsteopontinP53Response to neo-adjuvant chemotherapySurvivin

Identifiers

PMID29332262
PMCPMC5816118
OpenAlexW2783040510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.