Evidence map›Paper›PMID 29332257›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2018

Kynurenic acid and its derivatives are able to modulate the adhesion and locomotion of brain endothelial cells.

Eszter Lajkó, Bernadett Tuka, Ferenc Fülöp, István Krizbai, József Toldi, Kálmán Magyar, László Vécsei, László Kőhidai

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Eszter LajkóDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary.ORCID 0000-0002-4796-4646
Bernadett TukaMTA-SZTE Neuroscience Research Group, Semmelweis u. 6, Szeged, 6725, Hungary.ORCID 0000-0002-1410-4666
Ferenc FülöpInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary.ORCID 0000-0003-1066-5287
István KrizbaiInstitute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Temesvári krt. 62, Szeged, 6726, Hungary.ORCID 0000-0002-0764-1527
József ToldiMTA-SZTE Neuroscience Research Group, Semmelweis u. 6, Szeged, 6725, Hungary.ORCID 0000-0001-7355-0503
Kálmán MagyarDepartment of Pharmacodynamics, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary.ORCID 0000-0002-1852-3577
László VécseiMTA-SZTE Neuroscience Research Group, Semmelweis u. 6, Szeged, 6725, Hungary.ORCID 0000-0001-8037-3672
László KőhidaiDepartment of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary. kohlasz2@gmail.com.ORCID 0000-0002-9002-0296
Semmelweis University · HUUniversity of Szeged · HUHUN-REN Szegedi Biológiai Kutatóközpont · HUMTA-SZTE Research Group on Artificial Intelligence · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neuroprotective actions of kynurenic acid (KYNA) and its derivatives in several neurodegenerative disorders [characterized by damage to the cerebral endothelium and to the blood-brain barrier (BBB)] are well established. Cell-extracellular matrix (ECM) adhesion is supposedly involved in recovery of impaired cerebral endothelium integrity (endothelial repair). The present work aimed to investigate the effects of KYNA and its synthetic derivatives on cellular behaviour (e.g. adhesion and locomotion) and on morphology of the GP8 rat brain endothelial cell line, modeling the BBB endothelium. The effects of KYNA and its derivatives on cell adhesion were measured using an impedance-based technique, the xCELLigence SP system. Holographic microscopy (Holomonitor

Indexed as

AnimalsBlood-Brain BarrierCell AdhesionCell LineCell MovementEndothelial CellsKynurenic AcidNeuroprotective AgentsRatsKynurenic AcidNeuroprotective AgentsBrain endothelial cellEndothelial repairHolographic microscopyImpedimetryKynurenic acidKynurenic acid (PubChem CID: 3845)L-Kynurenine (Pubchem CID: 161166)Synthetic kynurenines

Identifiers

PMID29332257
OpenAlexW2783896051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.