ArticlePsychopharmacology2018
Dopamine-dependent social information processing in non-human primates.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Maternal immune activation alters infant attentional processing in a nonhuman primate model.Brain, behavior, & immunity - health · 2025Article
- Distinct Roles for Prefrontal Dopamine D1 and D2 Neurons in Social Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A Subpopulation of Prefrontal Cortical Neurons Is Required for Social Memory.Biological psychiatry · 2021Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
rationaleDopamine (DA) is a neurotransmitter whose roles have been suggested in various aspects of brain functions. Recent studies in rodents have reported its roles in social function. However, how DA is involved in social information processing in primates has largely remained unclear.
objectivesWe investigated prefrontal cortical (PFC) activities associated with social vs. nonsocial visual stimulus processing.
methodsNear-infrared spectroscopy (NIRS) was applied to Japanese macaques, along with pharmacological manipulations of DA transmission, while they were gazing at social and nonsocial visual stimuli.
resultsOxygenated (oxy-Hb) and deoxygenated (deoxy-Hb) hemoglobin changes as well as functional connectivity based on such Hb changes within the PFC network which were distinct between social and nonsocial stimuli were observed. Administration of both D1 and D2 receptor antagonists affected the Hb changes associated with social stimuli, whereas D1, but not D2, receptor antagonist affected the Hb changes associated with nonsocial stimuli.
conclusionsThese results suggest that mesocortical DA transmission in the PFC plays significant roles in social information processing, which involves both D1 and D2 receptor activation, in nonhuman primates. However, D1 and D2 receptor signaling in the PFC mediates different aspects of social vs. nonsocial information processing.
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