Evidence map›Paper›PMID 29332185›Full record

ArticleJournal of neuro-oncology2018

Handedness and the risk of glioma.

Briana Miller, Noah C Peeri, Louis Burt Nabors, Jordan H Creed, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Sajeel Chowdhary, Jeffrey J Olson, Reid C Thompson and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Briana MillerNeuro-Oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA.
Noah C PeeriDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612-9416, USA.
Louis Burt NaborsNeuro-Oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA.
Jordan H CreedDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612-9416, USA.
Zachary J ThompsonDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Carrie M RozmeskiDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612-9416, USA.
Renato V LaRoccaNorton Cancer Institute, 676 So Floyd St., Louisville, KY, 40202, USA.
Sajeel ChowdharyNeuro-Oncology Program, Lynn Cancer Institute, 701 NW 13th Street, Boca Raton, FL, 33486, USA.
Jeffrey J OlsonDepartment of Neurosurgery, Emory University School of Medicine, 1365-B Clifton Rd., NE, Ste. 2200, Atlanta, GA, 30322, USA.
Reid C ThompsonDepartment of Neurological Surgery, Vanderbilt University Medical Center, 691 Preston Building, Nashville, TN, 37232, USA.
Kathleen M EganDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612-9416, USA. Kathleen.egan@moffitt.org.ORCID http://orcid.org/0000-0001-8772-6979
Moffitt Cancer Center · USUniversity of Alabama at Birmingham · USEmory University · USLynn University · USNeurological Surgery · USNorton Healthcare · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
UAB CANCER RESEARCH EXPERIENCES FOR STUDENTS(CARES)R25CA076023 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PETER R., WATERBOR, JOHN W · 1999 to 2020
$5.6M
Southeast Region Case-Control Study of Adult GliomaR01CA116174 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI EGAN, KATHLEEN M. · 2007 to 2011
$4.9M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA116174NCI NIH HHS R25 CA076023NIH HHS R25 CA076023
6 · The paper itself

Abstract

Gliomas are the most common type of malignant primary brain tumor and few risk factors have been linked to their development. Handedness has been associated with several pathologic neurological conditions such as schizophrenia, autism, and epilepsy, but few studies have evaluated a connection between handedness and risk of glioma. In this study, we examined the relationship between handedness and glioma risk in a large case-control study (1849 glioma cases and 1354 healthy controls) and a prospective cohort study (326,475 subjects with 375 incident gliomas). In the case-control study, we found a significant inverse association between left handedness and glioma risk, with left-handed persons exhibiting a 35% reduction in the risk of developing glioma [odds ratio (OR) = 0.65, 95% confidence interval (CI) 0.51-0.83] after adjustment for age, gender, race, education, and state of residence; similar inverse associations were observed for GBM (OR = 0.69, 95% CI 0.52-0.91), and non-GBM (OR = 0.59, 95% CI 0.42-0.82) subgroups. The association was consistent in both males and females, and across age strata, and was observed in both glioblastoma and in lower grade tumors. In the prospective cohort study, we found no association between handedness and glioma risk (hazards ratio = 0.92, 95% CI 0.67-1.28) adjusting for age, gender, and race. Further studies on this association may help to elucidate mechanisms of pathogenesis in glioma.

Indexed as

Functional LateralityAdultAgedBrain NeoplasmsCase-Control StudiesFemaleGliomaHumansMaleMiddle AgedProspective StudiesRisk FactorsUnited KingdomCase–control studyCohort studyGlioblastomaGliomaHandednessUKBiobank

Identifiers

PMID29332185
PMCPMC5924459
OpenAlexW2783287092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.