Evidence map›Paper›PMID 29331497›Full record

ArticleThe Journal of nutritional biochemistry2018

Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.

Joseph F Pierre, Reinhard Hinterleitner, Romain Bouziat, Nathan A Hubert, Vanessa Leone, Jun Miyoshi, Bana Jabri, Eugene B Chang

Abstract read
In one paragraph

Article in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joseph F PierreSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Reinhard HinterleitnerSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Romain BouziatSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Nathan A HubertSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Vanessa LeoneSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Jun MiyoshiSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Bana JabriSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.
Eugene B ChangSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL.. Electronic address: echang@medicine.bsd.uchicago.edu.
University of Chicago · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Mutualistic relationship between Hsp25/27 and gut microbes as a major and essential determinant of mucosal healing and microbial fitness following intestinal injuryR01DK047722 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1993 to 2020
$4.3M
Cytoprotective Role of Heat Shock Proteins in IBDR37DK047722 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2008 to 2017
$3.8M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK047722NIDDK NIH HHS R01 DK097268NIDDK NIH HHS R37 DK047722
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD) are caused by the convergence of microbial, environmental, and genetic factors. Diet significantly alters these interactions by affecting both the host and microbiome. Using a mucosal inflammatory model that resembles the human condition of ileal pouchitis, we investigated the effects of Control (CONT) or Antioxidant (AOX) diet, containing pharmacologically relevant levels of 4 micronutrients, on disease risk in wild-type and IL-10

Indexed as

AnimalsAntioxidantsBody WeightCytokinesDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseImmunoglobulinsInflammatory Bowel DiseasesInterleukin-10Intestinal MucosaMice, Inbred C57BLMice, Mutant StrainsMicronutrientsSeleniumAntioxidantsCytokinesIL10 protein, mouseImmunoglobulinsInterleukin-10MicronutrientsSeleniumVitaminsAntioxidantsAscorbic acidInflammatory bowel diseasePouchitisRetinoic acidSelf-filling loopsUlcerative colitis

Identifiers

PMID29331497
PMCPMC5866768
OpenAlexW2774847405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.