Evidence map›Paper›PMID 29331482›Full record

ReviewGene2018

Genetic basis of hearing loss in Spanish, Hispanic and Latino populations.

Rahul Mittal, Amit P Patel, Desiree Nguyen, Debbie R Pan, Vasanti M Jhaveri, Jason R Rudman, Arjuna Dharmaraja, Denise Yan, Yong Feng, Prem Chapagain and 3 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Rahul MittalDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Amit P PatelDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Desiree NguyenDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Debbie R PanDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Vasanti M JhaveriDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Jason R RudmanDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Arjuna DharmarajaDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Denise YanDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Yong FengDepartment of Otolaryngology, Xiangya Hospital, Central South University, Changsha, China.
Prem ChapagainDepartment of Physics and Biomolecular Sciences Institute, Florida International University, Miami, FL, USA.
David J LeeDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Susan H BlantonDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Xue Zhong LiuDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, China; Tsinghua University School of Medicine, Beijing 10084, China; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address: xliu@med.miami.edu.
University of Miami · USCentral South University · CNFlorida International University · US

Funding

Molecular Genetics on Non Syndromic Hearing Loss (NSHL)R01DC005575 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIU, XUE Z · 2001 to 2024
$10.6M
Sensory disorders in COVID -19 as an early identifier and healthcare worker protectionR01DC012115 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIU, XUE Z · 2013 to 2022
$7.2M
NIDCD NIH HHS R01 DC005575NIDCD NIH HHS R01 DC012115
6 · The paper itself

Abstract

Hearing loss (HL) is the most common neurosensory disorder affecting humans. The screening, prevention and treatment of HL require a better understanding of the underlying molecular mechanisms. Genetic predisposition is one of the most common factors that leads to HL. Most HL studies include few Spanish, Hispanic and Latino participants, leaving a critical gap in our understanding about the prevalence, impact, unmet health care needs, and genetic factors associated with hearing impairment among Spanish, Hispanic and Latino populations. The few studies which have been performed show that the gene variants commonly associated with HL in non-Spanish and non-Hispanic populations are infrequently responsible for hearing impairment in Spanish as well as Hispanic and Latino populations (hereafter referred to as Hispanic). To design effective screening tools to detect HL in Spanish and Hispanic populations, studies must be conducted to determine the gene variants that are most commonly associated with hearing impairment in this racial/ethnic group. In this review article, we summarize gene variants and loci associated with HL in Spanish and Hispanic populations. Identifying new genetic variants associated with HL in Spanish and Hispanic populations will pave the way to develop effective screening tools and therapeutic strategies for HL.

Indexed as

AnimalsDeafnessEthnicityGenetic Predisposition to DiseaseHearing LossHispanic or LatinoHumansPrevalenceGenetic predispositionHearing lossHearing loss genesSpanish population, Hispanic and Latino populations

Identifiers

PMID29331482
PMCPMC5806531
OpenAlexW2783940794

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.