Evidence map›Paper›PMID 29331430›Full record

ArticleBiosensors & bioelectronics2018

Disposable inkjet-printed electrochemical platform for detection of clinically relevant HER-2 breast cancer biomarker.

Susanita Carvajal, Samantha N Fera, Abby L Jones, Thaisa A Baldo, Islam M Mosa, James F Rusling, Colleen E Krause

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Nanomaterial-Based Inkjet Printing for Electrochemical Sensing.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Multiplexed electrochemical assays for clinical applications.Current opinion in electrochemistry · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Flexible Sensing Systems for Cancer Diagnostics.Advances in experimental medicine and biology · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. 3D-Printed Immunosensor Arrays for Cancer Diagnostics.Sensors (Basel, Switzerland) · 2020
    Review
  19. Article
  20. Digital Manufacturing for Microfluidics.Annual review of biomedical engineering · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susanita CarvajalDepartment of Chemistry, University of Hartford, Bloomfield Ave., West Hartford, CT 06117, USA.
Samantha N FeraDepartment of Chemistry, University of Hartford, Bloomfield Ave., West Hartford, CT 06117, USA.
Abby L JonesDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd., Storrs, CT 06269, USA.
Thaisa A BaldoDepartment of Chemistry, Federal University of São Carlos, São Carlos 13565-905, SP, Brazil.
Islam M MosaDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd., Storrs, CT 06269, USA; Department of Chemistry, Tanta University, Tanta 31527, Egypt.
James F RuslingDepartment of Chemistry, University of Connecticut, 55 North Eagleville Rd., Storrs, CT 06269, USA; Department of Surgery & Neag Cancer Center, UConn, Health, 263 Farmington Avenue, Farmington, CT 06030, USA; Institute of Materials Science, University of Connecticut, 97 North Eagleville Road, Storrs, CT 06269, USA; School of Chemistry, National University of Ireland, University Road, Galway Ireland, Ireland.
Colleen E KrauseDepartment of Chemistry, University of Hartford, Bloomfield Ave., West Hartford, CT 06117, USA. Electronic address: ckrause@hartford.edu.

Funding

Protein Biomarker Arrays for Personalized Treatment of Prostate CancerR01EB016707 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI RUSLING, JAMES F. · 2014 to 2017
$1.4M
NIBIB NIH HHS R01 EB016707
6 · The paper itself

Abstract

Rapidly fabricated, disposable sensor platforms hold tremendous promise for point-of-care detection. Here, we present an inexpensive (< $0.25) fully inkjet printed electrochemical sensor with integrated counter, reference, and working electrodes that is easily scalable for commercial fabrication. The electrochemical sensor platform featured an inkjet printed gold working 8-electrode array (WEA) and counter electrode (CE), along with an inkjet -printed silver electrode that was chlorinated with bleach to produce a Ag/AgCl quasi-reference electrode (RE). As proof of concept, the electrochemical sensor was successfully applied for detection of clinically relevant breast cancer biomarker Human Epidermal Growth Factor Receptor 2 (HER-2). Capture antibodies were bound to a chemically modified surface on the WEA and placed into a microfluidic device. A full sandwich immunoassay was constructed following a simultaneous injection of target protein, biotinylated antibody, and polymerized horseradish peroxide labels into the microfluidic device housing the WEA. With an ultra fast assay time, of only 15mins a clinically relevant limit of detection of 12pgmL

Indexed as

Biosensing TechniquesAntibodiesBiomarkers, TumorBreast NeoplasmsElectrochemical TechniquesElectrodesErb-b2 Receptor Tyrosine KinasesFemaleGoldHumansLimit of DetectionPrintingAntibodiesBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGoldBreast cancerHuman epidermal growth factor receptor 2 (HER-2)ImmunoassayInkjet printingMicrofluidicPrinted electronics

Identifiers

PMID29331430
PMCPMC5794514

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.