ArticleHearing research2018
A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks.
Article in Hearing research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Precise spike-timing information in the brainstem is well aligned with the needs of communication and the perception of environmental sounds.PLoS biology · 2025Article
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- A computational model of auditory chirp-velocity sensitivity and amplitude-modulation tuning in inferior colliculus neurons.Journal of computational neuroscience · 2024Article
- A Computational Model of Auditory Chirp-Velocity Sensitivity and Amplitude-Modulation Tuning in Inferior Colliculus Neurons.Research square · 2024Article
- Article
- Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamic Heterogeneity Shapes Patterns of Spiral Ganglion Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Assessing temporal responsiveness of primary stimulated neurons in auditory brainstem and cochlear implant users.Hearing research · 2021Article
- Article
- Periodicity Pitch Perception.Frontiers in neuroscience · 2020Article
- Neuronal population model of globular bushy cells covering unit-to-unit variability.PLoS computational biology · 2019Article
- Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation.Neuroscience · 2019Review
- Dual Coding of Frequency Modulation in the Ventral Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Benefits of Enhanced Phase-Locking for Binaural Coding of Amplitude-Modulated Sounds.Trends in hearingArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Models of the auditory brainstem have been an invaluable tool for testing hypotheses about auditory information processing and for highlighting the most important gaps in the experimental literature. Due to the complexity of the auditory brainstem, and indeed most brain circuits, the dynamic behavior of the system may be difficult to predict without a detailed, biologically realistic computational model. Despite the sensitivity of models to their exact construction and parameters, most prior models of the cochlear nucleus have incorporated only a small subset of the known biological properties. This confounds the interpretation of modelling results and also limits the potential future uses of these models, which require a large effort to develop. To address these issues, we have developed a general purpose, biophysically detailed model of the cochlear nucleus for use both in testing hypotheses about cochlear nucleus function and also as an input to models of downstream auditory nuclei. The model implements conductance-based Hodgkin-Huxley representations of cells using a Python-based interface to the NEURON simulator. Our model incorporates most of the quantitatively characterized intrinsic cell properties, synaptic properties, and connectivity available in the literature, and also aims to reproduce the known response properties of the canonical cochlear nucleus cell types. Although we currently lack the empirical data to completely constrain this model, our intent is for the model to continue to incorporate new experimental results as they become available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.