Evidence map›Paper›PMID 29331218›Full record

ArticleSchizophrenia research2018

Knowing when to stop: Aberrant precision and evidence accumulation in schizophrenia.

Roberto Limongi, Bartosz Bohaterewicz, Magdalena Nowicka, Aleksandra Plewka, Karl J Friston

Abstract read
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Subcortical Origin of Salience Processing Deficits in Schizophrenia.Biological psychiatry global open science · 2023
    Article
  10. Review
  11. Active inference, morphogenesis, and computational psychiatry.Frontiers in computational neuroscience · 2022
    Article
  12. Review
  13. Article
  14. Neural Substrates of the Drift-Diffusion Model in Brain Disorders.Frontiers in computational neuroscience · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roberto LimongiUniversidad Tecnológica de Chile INACAP, Chile; Pontificia Universidad Católica de Valparaíso, Chile. Electronic address: roberto.limongi@fulbrightmail.org.
Bartosz BohaterewiczUniversity of Social Sciences and Humanities, Department of Psychology of Individual Differences, Warsaw, Poland; Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, Krakow, Poland.
Magdalena NowickaUniversity of Social Sciences and Humanities, Department of Psychology of Individual Differences, Warsaw, Poland.
Aleksandra PlewkaUniversity of Social Sciences and Humanities, Warsaw, Poland.
Karl J FristonWellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK.

Funding

Wellcome Trust 088130/Z/09/Z
6 · The paper itself

Abstract

Predictive coding and active inference formulations of the dysconnection hypothesis suggest that subjects with schizophrenia (SZ) hold unduly precise prior beliefs to compensate for a failure of sensory attenuation. This implies that SZ subjects should both initiate responses prematurely during evidence-accumulation tasks and fail to inhibit their responses at long stop-signal delays. SZ and healthy control subjects were asked to report the timing of billiards-ball collisions and were occasionally required to withhold their responses. SZ subjects showed larger temporal estimation errors, which were associated with premature responses and decreased response inhibition. To account for these effects, we used hierarchical (Bayesian) drift-diffusion models (HDDM) and model selection procedures to adjudicate among four hypotheses. HDDM revealed that the precision of prior beliefs (i.e., starting point) rather than increased sensory precision (i.e., drift rate) drove premature responses and impaired response inhibition in patients with SZ. From the perspective of active inference, we suggest that premature predictions in SZ are responses that, heuristically, are traded off against accuracy to ensure action execution. On the basis of previous work, we suggest that the right insular cortex might mediate this trade-off.

Indexed as

Inhibition, PsychologicalAdultAnticipation, PsychologicalExecutive FunctionFemaleHumansMaleMiddle AgedModels, TheoreticalPsychomotor PerformanceSchizophreniaActive inferenceDiffusion modelsDysconnection hypothesisResponse inhibitionSchizophreniaTemporal prediction

Identifiers

PMID29331218
PMCPMC6020132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.