ArticleAnnals of neurology2018
Terminal spreading depolarization and electrical silence in death of human cerebral cortex.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain-based arterial pulse pressure threshold for death determination: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Pooled it
- Detection and Quantification of Spreading Depolarization in Drosophila melanogaster Using High-Throughput, Wide-Field Brain Imaging.Current protocols · 2026Article
- [Controlled Donation after Circulatory determination of Death (cDCD) : A position paper by the DCD working group of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI)].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Review
- Increased Cannabinoid Receptor 1-Immunopositive Perisomatic Input of Principal Cells in Human Epileptic Patients in Focal Cortical Dysplasia Type IIB.International journal of molecular sciences · 2026Article
- Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death-Target for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Characterizing the physiology of circulatory arrest in humans.Nature medicine · 2025Observational
- Reduced brain oxygen response to spreading depolarization predicts worse outcome in ischaemic stroke.Brain : a journal of neurology · 2025Observational
- Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Contralesional hippocampal spreading depolarization promotes functional recovery after stroke.Nature communications · 2025Article
- Article
- Oxygen-Based Autoregulation Indices Associated with Clinical Outcomes and Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2025Observational
- Similarities in the Electrographic Patterns of Delayed Cerebral Infarction and Brain Death After Aneurysmal and Traumatic Subarachnoid Hemorrhage.Translational stroke research · 2025Review
- All Three Supersystems-Nervous, Vascular, and Immune-Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage.Translational stroke research · 2025Review
- Behavioral and Cognitive Consequences of Spreading Depolarizations: A Translational Scoping Review.Journal of neurotrauma · 2025Article
- Lessons to Learn from Multimodal Neuromonitoring of Brain Death with Electrophysiological Markers of Cortical and Subcortical Loss of Functions.Neurocritical care · 2024Article
- Organellular imagingbioRxiv : the preprint server for biology · 2024Article
- Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia.Reviews in the neurosciences · 2024Review
- Electrophysiological monitoring of neurological functions at the acute phase of brain injury: An overview of current knowledge and future perspectives in the adult population.European journal of anaesthesiology and intensive care · 2024Review
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Spatial and Temporal Comparisons of Calcium Channel and Intrinsic Signal Imaging During in Vivo Cortical Spreading Depolarizations in Healthy and Hypoxic Brains.Neurocritical care · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveRestoring the circulation is the primary goal in emergency treatment of cerebral ischemia. However, better understanding of how the brain responds to energy depletion could help predict the time available for resuscitation until irreversible damage and advance development of interventions that prolong this span. Experimentally, injury to central neurons begins only with anoxic depolarization. This potentially reversible, spreading wave typically starts 2 to 5 minutes after the onset of severe ischemia, marking the onset of a toxic intraneuronal change that eventually results in irreversible injury.
methodsTo investigate this in the human brain, we performed recordings with either subdural electrode strips (n = 4) or intraparenchymal electrode arrays (n = 5) in patients with devastating brain injury that resulted in activation of a Do Not Resuscitate-Comfort Care order followed by terminal extubation.
resultsWithdrawal of life-sustaining therapies produced a decline in brain tissue partial pressure of oxygen (p
interpretationThese results provide fundamental insight into the neurobiology of dying and have important implications for survivable cerebral ischemic insults. Ann Neurol 2018;83:295-310.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.