ArticleThoracic cancer2018
Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways.
Article in Thoracic cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Bisphenol A and breast cancer: Can mechanistic plausibility be reconciled with epidemiological inconsistency?iScience · 2026Review
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Melatonin Attenuates Mitochondrial Damage in Aristolochic Acid-Induced Acute Kidney Injury.Biomolecules & therapeutics · 2023Article
- The Effect of Melatonin Intake on Survival of Patients with Breast Cancer-A Population-Based Registry Study.Cancers · 2022Article
- Can Antioxidants Reduce the Toxicity of Bisphenol?Antioxidants (Basel, Switzerland) · 2022Review
- Melatonin and its mechanism of action in the female reproductive system and related malignancies.Molecular and cellular biochemistry · 2021Review
- Review
- Steroid receptor coactivator-1 enhances the stemness of glioblastoma by activating long noncoding RNA XIST/miR-152/KLF4 pathway.Cancer science · 2021Article
- Role and Therapeutic Potential of Melatonin in Various Type of Cancers.OncoTargets and therapy · 2021Review
- Endocrine Disruptors as a New Etiologic Factor of Bone Tissue Diseases (Review).Sovremennye tekhnologii v meditsine · 2021Review
- ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer.Frontiers in oncology · 2020Article
- 17β‑estradiol‑induced mitochondrial dysfunction and Warburg effect in cervical cancer cells allow cell survival under metabolic stress.International journal of oncology · 2020Article
- Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.Nature reviews. Endocrinology · 2020Review
- Review
- Bisphenol A co-exposure effects: a key factor in understanding BPA's complex mechanism and health outcomes.Critical reviews in toxicology · 2019Review
- Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular GInternational journal of molecular sciences · 2019Article
- BPA and Nutraceuticals, Simultaneous Effects on Endocrine Functions.Endocrine, metabolic & immune disorders drug targets · 2019Review
- Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis.OncoTargets and therapy · 2018Article
- Effects of melatonin on diabetic nephropathy rats via Wnt/β-catenin signaling pathway and TGF-β-Smad signaling pathway.International journal of clinical and experimental pathology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBackground: Bisphenol A (BPA) is an estrogen-like chemical widely contained in daily supplies. There is evidence that environmental exposure to BPA could contribute to the development of hormone-related cancers. As is reported in numerous studies, melatonin, an endogenous hormone secreted by the pineal gland, could markedly inhibit estrogen-induced proliferation of breast cancer (BC) cells. In this study, we intended to reveal the effects of melatonin on BPA-induced proliferation of estrogen receptor-positive BC cells.
methodsMethods: We used methyl thiazolyl tetrazolium, luciferase reporter gene and western blotting assays to testify the effect of melatonin on BPA-mediated proliferation of MCF-7 and T47D cells.
resultsMethyl thiazolyl tetrazolium and colony formation assays showed that melatonin could significantly abolish BPA-elevated cell proliferation. Meanwhile, BPA-upregulated phosphorylation of ERK and AKT was decreased by melatonin treatment. Mechanistically, we found that BPA was capable of upregulating the protein levels of steroid receptor coactivators (SRC-1, SRC-3), as well as promoting the estrogen response element activity. However, the addition of melatonin could remarkably block the elevation of steroid receptor coactivators expression and estrogen response element activity triggered by BPA.
conclusionConclusions: Therefore, these results demonstrated that melatonin could abrogate BPA-induced proliferation of BC cells. Therapeutically, melatonin could be regarded as a potential medication for BPA-associated BC.
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Registered trials
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