Evidence map›Paper›PMID 29330760›Full record

ArticleAngiogenesis2018

Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms.

Taras Afonyushkin, Olga V Oskolkova, Valery N Bochkov

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angiogenesis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Taras AfonyushkinCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25-3, 1090, Vienna, Austria.
Olga V OskolkovaDepartment of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Humboldtstrasse 46/III, 8010, Graz, Austria.
Valery N BochkovDepartment of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Humboldtstrasse 46/III, 8010, Graz, Austria. valery.bochkov@uni-graz.at.
University of Graz · ATCeMM Research Center for Molecular Medicine · AT

Funding

Austrian Science Fund FWF P23016-B11Austrian Science Fund FWF P27682-B30
6 · The paper itself

Abstract

Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis demonstrated OxPAPC-induced upregulation of SCF mRNA and protein in different types of endothelial cells (ECs). Elevated levels of SCF mRNA were observed in aortas of ApoE

Indexed as

Gene Expression RegulationAnimalsAortaApolipoproteins EHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Knockout, ApoENF-E2-Related Factor 2Oxidation-ReductionPhosphatidylcholinesStem Cell FactorApolipoproteins ENfe2l2 protein, mouseNF-E2-Related Factor 2PhosphatidylcholinesStem Cell FactorAtherosclerosisc-KitElectrophilic stress responseNRF2Oxidized phospholipidsSCF

Identifiers

PMID29330760
PMCPMC5878191
OpenAlexW2783012412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.