Evidence map›Paper›PMID 29330552›Full record

ArticleScientific reports2018

Dosimetry Prediction for Clinical Translation of

Arutselvan Natarajan, Chirag B Patel, Frezghi Habte, Sanjiv S Gambhir

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  2. Ultra-low dose immunoPET usingFrontiers in medicine · 2025
    Article
  3. Review
  4. Methods for the Production of Radiolabeled Bioagents for ImmunoPET.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  5. Review
  6. Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Imaging in Tumor Immunology.Nuclear medicine and molecular imaging · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Journal for immunotherapy of cancer · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Arutselvan NatarajanDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Chirag B PatelDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Frezghi HabteDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States.
Sanjiv S GambhirDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United States. sgambhir@stanford.edu.
Stanford University · US

Funding

Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
NCI NIH HHS P50 CA114747
6 · The paper itself

Abstract

The immune checkpoint programmed death 1 receptor (PD-1) expressed on some tumor-infiltrating lymphocytes, and its ligand (PD-L1) expressed on tumor cells, enable cancers to evade the immune system. Blocking PD-1 with the monoclonal antibody pembrolizumab is a promising immunotherapy strategy. Thus, noninvasively quantifying the presence of PD-1 expression in the tumor microenvironment prior to initiation of immune checkpoint blockade may identify the patients likely to respond to therapy. We have developed a

Indexed as

AnimalsAntibodies, Monoclonal, HumanizedCell Line, TumorCopper RadioisotopesHumansMelanomaMiceNeoplasm TransplantationPositron Emission Tomography Computed TomographyProgrammed Cell Death 1 ReceptorRadioactive TracersRadiometryTranslational Research, BiomedicalTumor MicroenvironmentAntibodies, Monoclonal, HumanizedCopper-64Copper RadioisotopesPDCD1 protein, humanpembrolizumabProgrammed Cell Death 1 ReceptorRadioactive Tracers

Identifiers

PMID29330552
PMCPMC5766550
OpenAlexW2782710178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.