Evidence map›Paper›PMID 29330505›Full record

ArticleScientific reports2018

Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance.

Alexis Ruiz, Erez Dror, Christoph Handschin, Regula Furrer, Joaquin Perez-Schindler, Christoph Bachmann, Susan Treves, Francesco Zorzato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  10. Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Alexis RuizDepartments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland.
Erez DrorMax Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg, Germany.
Christoph HandschinBiozentrum, University of Basel, CH-4056, Basel, Switzerland.ORCID http://orcid.org/0000-0003-0603-1097
Regula FurrerBiozentrum, University of Basel, CH-4056, Basel, Switzerland.
Joaquin Perez-SchindlerBiozentrum, University of Basel, CH-4056, Basel, Switzerland.
Christoph BachmannDepartments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland.
Susan TrevesDepartments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland.
Francesco ZorzatoDepartments of Anesthesia and of Biomedicine, Basel University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland. zor@unife.it.
University of Basel · CHUniversity Hospital of Basel · CHUniversity of Ferrara · ITMax Planck Institute of Immunobiology and Epigenetics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance in vivo, which is not related to alterations in excitation-contraction coupling but rather linked to enhanced glucose metabolism. Over-expression of SRP-35 causes increased phosphorylation of Akt

Indexed as

AnimalsGene ExpressionGlucoseGlucose Transporter Type 4MaleMAP Kinase Signaling SystemMechanistic Target of Rapamycin Complex 2MiceMice, TransgenicMuscle, SkeletalOxidoreductasesPhosphorylationReceptors, Retinoic AcidRetinoic Acid Receptor alphaDHRS7C protein, mouseGlucoseGlucose Transporter Type 4Mechanistic Target of Rapamycin Complex 2OxidoreductasesRara protein, mouseReceptors, Retinoic AcidRetinoic Acid Receptor alpharetinoic acid receptor betaSlc2a4 protein, mouse

Identifiers

PMID29330505
PMCPMC5766524
OpenAlexW2783490702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.