ArticleScientific reports2018
Replication of biocompatible, nanotopographic surfaces.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Evaluation of Probiotic Growth in Microenvironments Sculpted with Different Geometries.ACS omega · 2025Article
- Nanotopographic control of actin waves and growth cone navigation in developing neurons.Frontiers in cell and developmental biology · 2025Article
- Article
- Assessing the stability of azopolymer nanotopography during live-cell fluorescence imaging.Frontiers in bioengineering and biotechnology · 2024Article
- Nanotopography modulates cytoskeletal organization and dynamics during T cell activation.Molecular biology of the cell · 2022Article
- 3D printing of nanowrinkled architectures via laser direct assembly.Science advances · 2022Article
- Biomaterials to enhance stem cell transplantation.Cell stem cell · 2022Review
- Article
- Actin Dynamics as a Multiscale Integrator of Cellular Guidance Cues.Frontiers in cell and developmental biology · 2022Article
- Two-Photon Polymerization: Functionalized Microstructures, Micro-Resonators, and Bio-Scaffolds.Polymers · 2021Review
- New perspectives on the roles of nanoscale surface topography in modulating intracellular signaling.Current opinion in solid state & materials science · 2021Article
- Quantifying topography-guided actin dynamics across scales using optical flow.Molecular biology of the cell · 2020Article
- Actin Cytoskeleton and Focal Adhesions Regulate the Biased Migration of Breast Cancer Cells on Nanoscale Asymmetric Sawteeth.ACS nano · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ability of cells to sense and respond to nanotopography is being implicated as a key element in many physiological processes such as cell differentiation, immune response, and wound healing, as well as in pathologies such as cancer metastasis. To understand how nanotopography affects cellular behaviors, new techniques are required for the mass production of biocompatible, rigid nanotopographic surfaces. Here we introduce a method for the rapid and reproducible production of biocompatible, rigid, acrylic nanotopographic surfaces, and for the functionalization of the surfaces with adhesion-promoting molecules for cell experiments. The replica surfaces exhibit high optical transparency, which is advantageous for high-resolution, live-cell imaging. As a representative application, we demonstrate that epithelial cells form focal adhesions on surfaces composed of nanoscale ridges and grooves, and that the focal adhesions prefer to localize on the nanoridges. We further demonstrate that both F-actin and microtubules align along the nanoridges, but only F-actin aligns along the nanogrooves. The mass production of nanotopographic surfaces opens the door to the investigation of the effect of physical cues on the spatial distribution and the dynamics of intracellular proteins, and to the study of the mechanism of mechanosensing in processes such as cell migration, phagocytosis, division, and differentiation.
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