Evidence map›Paper›PMID 29330480›Full record

ArticleScientific reports2018

Anti-correlated cortical networks arise from spontaneous neuronal dynamics at slow timescales.

Nathan X Kodama, Tianyi Feng, James J Ullett, Hillel J Chiel, Siddharth S Sivakumar, Roberto F Galán

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Brain-wide functional connectivity of face patch neurons during rest.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
  5. Article
  6. Emergence of Neuronal Synchronisation in Coupled Areas.Frontiers in computational neuroscience · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathan X KodamaDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Tianyi FengDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
James J UllettDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Hillel J ChielDepartment of Biology, Case Western Reserve University, Cleveland, Ohio, 44106, USA.ORCID http://orcid.org/0000-0002-1750-8500
Siddharth S SivakumarDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, 44106, USA.ORCID http://orcid.org/0000-0002-8621-5867
Roberto F GalánDepartment of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, 44106, USA. rfgalan@case.edu.ORCID http://orcid.org/0000-0003-1426-1917

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the highly interconnected architectures of the cerebral cortex, recurrent intracortical loops disproportionately outnumber thalamo-cortical inputs. These networks are also capable of generating neuronal activity without feedforward sensory drive. It is unknown, however, what spatiotemporal patterns may be solely attributed to intrinsic connections of the local cortical network. Using high-density microelectrode arrays, here we show that in the isolated, primary somatosensory cortex of mice, neuronal firing fluctuates on timescales from milliseconds to tens of seconds. Slower firing fluctuations reveal two spatially distinct neuronal ensembles, which correspond to superficial and deeper layers. These ensembles are anti-correlated: when one fires more, the other fires less and vice versa. This interplay is clearest at timescales of several seconds and is therefore consistent with shifts between active sensing and anticipatory behavioral states in mice.

Indexed as

AnimalsMiceNeuronsSomatosensory CortexSpatio-Temporal AnalysisSynaptic Transmission

Identifiers

PMID29330480
PMCPMC5766587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.