Evidence map›Paper›PMID 29330460›Full record

ArticleScientific reports2018

Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training.

Jackson J Fyfe, David J Bishop, Jonathan D Bartlett, Erik D Hanson, Mitchell J Anderson, Andrew P Garnham, Nigel K Stepto

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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  20. Reduced Physical Activity Alters the Leucine-Stimulated Translatome in Aged Skeletal Muscle.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Jackson J FyfeInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia. jackson.fyfe@deakin.edu.au.ORCID http://orcid.org/0000-0002-9541-2336
David J BishopInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.
Jonathan D BartlettInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.
Erik D HansonInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.ORCID http://orcid.org/0000-0002-7744-5652
Mitchell J AndersonInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.
Andrew P GarnhamInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.
Nigel K SteptoInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.ORCID http://orcid.org/0000-0002-0875-6836
Deakin University · AUVictoria University · AUEdith Cowan University · AUThe University of Melbourne · AUUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training versus RT alone. Twenty-three males underwent eight weeks of RT, either performed alone (RT group, n = 8), or combined with either high-intensity interval training (HIT+RT group, n = 8), or moderate-intensity continuous training (MICT+RT group, n = 7). Muscle samples (vastus lateralis) were obtained before training, and immediately before, 1 h and 3 h after the final training session. Training-induced changes in basal expression of the 45S ribosomal RNA (rRNA) precursor (45S pre-rRNA), and 5.8S and 28S mature rRNAs, were greater with concurrent training versus RT. However, during the final training session, RT further increased both mTORC1 (p70S6K1 and rps6 phosphorylation) and 45S pre-rRNA transcription-related signalling (TIF-1A and UBF phosphorylation) versus concurrent training. These data suggest that when performed in a training-accustomed state, RT induces further increases mTORC1 and ribosome biogenesis-related signalling in human skeletal muscle versus concurrent training; however, changes in ribosome biogenesis markers were more favourable following a period of short-term concurrent training versus RT performed alone.

Indexed as

High-Intensity Interval TrainingHumansMaleMechanistic Target of Rapamycin Complex 1Muscle, SkeletalPhysical Conditioning, HumanResistance TrainingRibosomesRNA, RibosomalRNA, Ribosomal, 28SRNA, Ribosomal, 5.8SSignal TransductionMechanistic Target of Rapamycin Complex 1RNA, RibosomalRNA, Ribosomal, 28SRNA, ribosomal, 45SRNA, Ribosomal, 5.8S

Identifiers

PMID29330460
PMCPMC5766515
OpenAlexW2952178653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.