ArticleScientific reports2018
Beta-catenin cleavage enhances transcriptional activation.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Ferroptosis as a Novel Therapeutic Strategy to Overcome Multidrug Resistance in Colorectal Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Review
- High serum LDL promotes EMT and stemness through LDLR/FOXQ1/NF-κB1 pathway in epithelial ovarian cancer.Oncogene · 2025Article
- PDZ domain containing protein 1 aggravates mouse vascular smooth muscle cells calcification via PDZ1 domain mediated β-catenin stabilization and nuclear translocation.Communications biology · 2025Article
- Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2.EMBO molecular medicine · 2025Article
- Phosphatidylinositol 3-Kinase Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation.The American journal of pathology · 2025Article
- RAIDS atlas of significant genetic and protein biomarkers in cervical cancer.Journal of gynecologic oncology · 2023Review
- eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance.iScience · 2023Article
- Role of a Disease-associated ST3Gal-4 in Non-small Cell Lung Cancer.Cell biochemistry and biophysics · 2022Article
- Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction.JACC. Basic to translational science · 2022Article
- G9a Knockdown Suppresses Cancer Aggressiveness by Facilitating Smad Protein Phosphorylation through Increasing BMP5 Expression in Luminal A Type Breast Cancer.International journal of molecular sciences · 2022Article
- Traditional chinese medicine syndromes classification associates with tumor cell and microenvironment heterogeneity in colorectal cancer: a single cell RNA sequencing analysis.Chinese medicine · 2021Article
- Phytate and Butyrate Differently Influence the Proliferation, Apoptosis and Survival Pathways in Human Cancer and Healthy Colonocytes.Nutrients · 2021Article
- Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials.International journal of molecular sciences · 2020Review
- Genetic markers and phosphoprotein forms of beta-catenin pβ-Cat552 and pβ-Cat675 are prognostic biomarkers of cervical cancer.EBioMedicine · 2020Article
- Dynamic Expression Profiles of β-Catenin during Murine Cardiac Valve Development.Journal of cardiovascular development and disease · 2020Article
- Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism.Scientific reports · 2020Article
- CD103 Deficiency Promotes Autism (ASD) and Attention-Deficit Hyperactivity Disorder (ADHD) Behavioral Spectra and Reduces Age-Related Cognitive Decline.Frontiers in neurology · 2020Article
- SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation.Cellular and molecular gastroenterology and hepatology · 2020Article
- An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.EBioMedicine · 2019Article
- Adenosine AFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Tatiana GoretskyDepartment of Internal Medicine, Division of Gastroenterology, University of Kentucky, Lexington, KY, USA.
Emily M BradfordDepartment of Internal Medicine, Division of Gastroenterology, University of Kentucky, Lexington, KY, USA.
Qing YeMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Olivia F LampingDepartment of Internal Medicine, Division of Gastroenterology, University of Kentucky, Lexington, KY, USA.
Tomas VanagunasLouisiana State University Health Sciences Center, New Orleans, LA, USA.
Mary Pat MoyerINCELL Corporation, San Antonio, TX, USA.
Patrick C KellerDepartment of Internal Medicine, Division of Gastroenterology, University of Kentucky, Lexington, KY, USA.
Preetika SinhNorthwestern University, Chicago, IL, USA.
Josep M LlovetThe Mount Sinai Hospital, New York, NY, USA.ORCID http://orcid.org/0000-0003-0547-2667
Tianyan GaoMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Qing-Bai SheMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-7207-0599
Linheng LiStowers Institute for Medical Research, Kansas City, MO, USA.ORCID http://orcid.org/0000-0001-9963-430X
Terrence A BarrettDepartment of Internal Medicine, Division of Gastroenterology, University of Kentucky, Lexington, KY, USA. t.barrett@uky.edu.
University of Kentucky · USIncell Corporation (United States) · USLouisiana State University Health Sciences Center New Orleans · USMount Sinai Hospital · USNorthwestern University · USStowers Institute for Medical Research · US
Funding
Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5MIsolation and Characterization of Intestinal Stem CellsU01DK085507 · NIDDK · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI LI, LINHENG · 2009 to 2023
$6.2MThe Role of PHLPP in Colon CancerR01CA133429 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GAO, TIANYAN · 2009 to 2024
$5.6MTRAINING PROGRAM IN ONCOGENESIS &DEVELOPMENT BIOLOGYT32CA080621 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI EKLUND, ELIZABETH ANN · 2001 to 2018
$4.1MThe Role of Crypt Fissioning in IBD Ulcer HealingR01DK095662 · NIDDK · UNIVERSITY OF KENTUCKY · PI BARRETT, TERRENCE A. · 2012 to 2024
$3.9MTargeting Translation Dependence in Colorectal Cancer ProgressionR01CA175105 · NCI · UNIVERSITY OF KENTUCKY · PI SHE, QING-BAI · 2013 to 2024
$3.3MLimited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3MThe role of Axin2+ stem cells in ulcer healing during colitis.I01CX001353 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI Terrence A. Barrett · 2017 to 2026
–CSRD VA I01 CX001353NCI NIH HHS R01 CA133429NCI NIH HHS R01 CA175105NCI NIH HHS T32 CA080621NIDDK NIH HHS R01 DK095662NIDDK NIH HHS U01 DK085507NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U24 DK085532
Abstract
Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and cancer. Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat
Indexed as
Transcriptional ActivationAnimalsbeta CateninCaco-2 CellsCell Line, TumorCell NucleusCell ProliferationColitisColorectal NeoplasmsHCT116 CellsHT29 CellsHumansMiceMolecular WeightMutationNeoplasm Transplantationbeta CateninCTNNB1 protein, humanProteasome Endopeptidase ComplexTCF4 protein, humanTranscription Factor 4
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.