ArticleScientific reports2018
Glucose-independent segmental phase angles from multi-frequency bioimpedance analysis to discriminate diabetes mellitus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Phase angle as a marker of outcome in hospitalized pediatric patients. A systematic review of the evidence (GRADE) with meta-analysis.Reviews in endocrine & metabolic disorders · 2023Pooled it
- Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies.Nutrition & diabetes · 2026Article
- Phase angle as a potential marker of early nutritional and metabolic changes following metabolic bariatric surgery: a retrospective study.Frontiers in nutrition · 2026Article
- Comparison of clip and needle electrodes for multifrequency bioimpedance analysis in anesthetized dogs.PloS one · 2026Article
- Phase Angle Evaluated by a Bioimpedance Analysis Is Closely Related to Diabetic Nephropathy and Peripheral Neuropathy in Patients with Type 2 Diabetes.JMA journal · 2025Article
- Examining Classic Bioimpedance Vector Patterns Between BMI Classifications Among Community-Dwelling Older Women.Sensors (Basel, Switzerland) · 2025Article
- Stronger associations of the phase angle than the TyG index with micro- and macrovascular complications in patients with type 2 diabetes.Lipids in health and disease · 2025Article
- Exploring the significance of phase angle in diabetes management: a narrative review.Diabetology international · 2025Review
- Phase angle in bioelectrical impedance analysis for assessing congestion in acute heart failure.PloS one · 2025Article
- Whole-Body and Segmental Phase Angles and Cognitive Function in the Older Korean Population: Cross-Sectional Analysis.JMIR public health and surveillance · 2024Article
- Association of bio-impedance phase angle and a nutritional indicator in community-dwelling patients with type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2024Article
- Phase angle and body composition in long-term type 1 diabetes in adults: a comparative study in a Brazilian public reference outpatient clinic.Diabetology & metabolic syndrome · 2024Article
- Exploring the association between phase angle of bioimpedance at 50 kHz and cardiovascular risk.BMC cardiovascular disorders · 2024Article
- Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2024Observational
- Comparing Device-Generated and Calculated Bioimpedance Variables in Community-Dwelling Older Adults.Sensors (Basel, Switzerland) · 2024Article
- Agreement Between Bioelectrical Impedance Analysis and Dual-Energy X-ray Absorptiometry to Estimate Fat Mass in Hispanic Adults With Type 2 Diabetes Mellitus: A Cross-Sectional Study.Clinical medicine insights. Endocrinology and diabetes · 2024Article
- Phase angle at bioelectric impedance analysis is associated with detrimental sperm quality in idiopathic male infertility: a preliminary clinical study.Frontiers in endocrinology · 2024Article
- A screening method for mild cognitive impairment in elderly individuals combining bioimpedance and MMSE.Frontiers in aging neuroscience · 2024Article
- Association of a Bioimpedance Profile with Optical Coherence Tomography Features in Diabetic Macular Edema.Journal of clinical medicine · 2023Article
- Determinants of phase angle in Japanese patients with diabetes.Diabetology international · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated segmental phase angles (PAs) in the four limbs using a multi-frequency bioimpedance analysis (MF-BIA) technique for noninvasively diagnosing diabetes mellitus. We conducted a meal tolerance test (MTT) for 45 diabetic and 45 control subjects stratified by age, sex and body mass index (BMI). HbA1c and the waist-to-hip-circumference ratio (WHR) were measured before meal intake, and we measured the glucose levels and MF-BIA PAs 5 times for 2 hours after meal intake. We employed a t-test to examine the statistical significance and the area under the curve (AUC) of the receiver operating characteristics (ROC) to test the classification accuracy using segmental PAs at 5, 50, and 250 kHz. Segmental PAs were independent of the HbA1c or glucose levels, or their changes caused by the MTT. However, the segmental PAs were good indicators for noninvasively screening diabetes In particular, leg PAs in females and arm PAs in males showed best classification accuracy (AUC = 0.827 for males, AUC = 0.845 for females). Lastly, we introduced the PA at maximum reactance (PAmax), which is independent of measurement frequencies and can be obtained from any MF-BIA device using a Cole-Cole model, thus showing potential as a useful biomarker for diabetes.
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