Evidence map›Paper›PMID 29330414›Full record

ArticleScientific reports2018

Partially oxidized polyvinyl alcohol conduitfor peripheral nerve regeneration.

Elena Stocco, Silvia Barbon, Lucia Lora, Francesca Grandi, Leonardo Sartore, Cesare Tiengo, Lucia Petrelli, Daniele Dalzoppo, Pier Paolo Parnigotto, Veronica Macchi and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Restoration of Neurological Function Following Peripheral Nerve Trauma.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elena StoccoSection of Human Anatomy, Department of Neurosciences, University of Padua, Via Gabelli 65, 35121, Padua, Italy.
Silvia BarbonDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Via Marzolo 5, 35131, Padua, Italy.
Lucia LoraDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Via Marzolo 5, 35131, Padua, Italy.
Francesca GrandiDepartment of Women's and Children's Health, Pediatric Surgery, University of Padua, Via Giustiniani 3, 35121, Padua, Italy.
Leonardo SartoreDepartment of Plastic and Reconstructive Surgery, Ospedale Sant'Anna, Via Napoleona 60, 22100, Como, Italy.
Cesare TiengoClinic of Plastic Surgery, Department of Neurosciences, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
Lucia PetrelliSection of Human Anatomy, Department of Neurosciences, University of Padua, Via Gabelli 65, 35121, Padua, Italy.
Daniele DalzoppoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Via Marzolo 5, 35131, Padua, Italy.
Pier Paolo ParnigottoFoundation for Biology and Regenerative Medicine, Tissue Engineering and Signaling (TES) ONLUS, Via De Sanctis 10, Caselle di Selvazzano Dentro, 35030, Padua, Italy.
Veronica MacchiSection of Human Anatomy, Department of Neurosciences, University of Padua, Via Gabelli 65, 35121, Padua, Italy.
Raffaele De CaroSection of Human Anatomy, Department of Neurosciences, University of Padua, Via Gabelli 65, 35121, Padua, Italy.
Andrea PorzionatoSection of Human Anatomy, Department of Neurosciences, University of Padua, Via Gabelli 65, 35121, Padua, Italy. andrea.porzionato@unipd.it.
Claudio GrandiDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Via Marzolo 5, 35131, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical reconstruction of peripheral nerves injuries with wide substance-loss is still a challenge. Many studies focused on the development of artificial nerve conduits made of synthetic or biological materials but the ideal device has not yet been identified. Here, we manufactured a conduit for peripheral nerve regeneration using a novel biodegradable hydrogel we patented that is oxidized polyvinyl alcohol (OxPVA). Thus, its characteristics were compared with neat polyvinyl alcohol (PVA) and silk-fibroin (SF) conduits, through in vitro and in vivo analysis. Unlike SF, OxPVA and neat PVA scaffolds did not support SH-SY5Y adhesion and proliferation in vitro. After implantation in rat model of sciatic nerve transection, the three conduits sustained the regeneration of the injured nerve filling a gap of 5 mm in 12 weeks. Implanted animals showed a good gait recovery. Morphometric data related to the central portion of the explanted conduit interestingly highlighted a significantly better outcome for OxPVA scaffolds compared to PVA conduits in terms of axon density, also with respect to the autograft group. This study suggests the potential of our novel biomaterial for the development of conduits for clinical use in case of peripheral nerve lesions with substance loss.

Indexed as

AnimalsCell AdhesionCell LineCell ProliferationDisease Models, AnimalFibroinsHumansHydrogelsNerve RegenerationPeripheral Nerve InjuriesPolyvinyl AlcoholRatsTissue ScaffoldsFibroinsfibroin, silkwormHydrogelsPolyvinyl Alcohol

Identifiers

PMID29330414
PMCPMC5766572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.