ArticleScientific reports2018
Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Biomaterials for fetal membrane repair in preterm premature rupture of membranes: advances in tissue engineering strategies.Journal of biological engineering · 2025Review
- Role of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical Stimulation.Prenatal diagnosis · 2025Article
- Amniotic Fluid Proteomics Analysis and In Vitro Validation to Identify Potential Biomarkers of Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Frontiers in the Etiology and Treatment of Preterm Premature Rupture of Membrane: From Molecular Mechanisms to Innovative Therapeutic Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Human-Derived collagen hydrogel as an antibiotic vehicle for topical treatment of bacterial biofilms.PloS one · 2024Article
- Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches.Biomedicines · 2023Review
- Integrin β1 is a key determinant of the expression of angiotensin-converting enzyme 2 (ACE2) in the kidney epithelial cells.European journal of cell biology · 2023Article
- A collagen plug with shape memory to seal iatrogenic fetal membrane defects after fetoscopic surgery.Bioactive materials · 2023Article
- The role of intraamniotic inflammation in threatened midtrimester miscarriage.American journal of obstetrics and gynecology · 2022Article
- Article
- Possible important roles of galectins in the healing of human fetal membranes.Frontiers in endocrinology · 2022Review
- Comprehensive quantitative characterization of the human term amnion proteome.Matrix biology plus · 2021Article
- Progesterone receptor membrane components: key regulators of fetal membrane integrity.Biology of reproduction · 2021Article
- Reversible EMT and MET mediate amnion remodeling during pregnancy and labor.Science signaling · 2020Article
- Healing Mechanism of Ruptured Fetal Membrane.Frontiers in physiology · 2020Review
- Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Preterm premature rupture of membranes (pPROM) is a major cause of preterm birth. Recently, extracellular matrix-directed treatment is applied for wound healing. Here, we used a pregnant mouse model to test the efficacy of collagen type 1 gel for healing of the prematurely ruptured fetal membranes. Although injection of PBS into the ruptured fetal membranes resulted in 40% closure, injection of collagen type 1 improved closure rates to 90% within 72 h. Macrophages of the M2 wound healing phenotype were entrapped in the collagen layer. In primary human amnion mesenchymal cells, collagen type 1 gels activated collagen receptor discoidin domain receptor 2 (DDR2) to induce myosin light chain phosphorylation and migration of injured amnion mesenchymal cells. These findings define the mechanisms for matrix-directed therapeutics for pPROM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.