ArticleScientific reports2018
Identification of shared genetic variants between schizophrenia and lung cancer.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Lung cancer incidence in patients with schizophrenia: meta-analysis.The British journal of psychiatry : the journal of mental science · 2019Pooled it
- Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress.European archives of psychiatry and clinical neuroscience · 2026Review
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Genetic overlap between treatment-resistant schizophrenia and smoking initiation.The international journal of neuropsychopharmacology · 2026Article
- A multi-level exploration of the genetic basis between lung cancer and schizophrenia.Annals of general psychiatry · 2025Article
- Genetic prediction of the causal relationship between schizophrenia and tumors: a Mendelian randomized study.Frontiers in oncology · 2024Article
- Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy.Scientific reports · 2023Article
- Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment?International journal of molecular sciences · 2022Review
- Case report: Schizophrenia and hypertrophic osteoarthropathy, a rare syndrome hiding a life-threatening condition.Clinical case reports · 2022Article
- Accurate error control in high-dimensional association testing using conditional false discovery rates.Biometrical journal. Biometrische Zeitschrift · 2021Article
- The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.Human genetics · 2021Article
- Overlapping Genetic Architecture Between Schizophrenia and Neurodegenerative Disorders.Frontiers in cell and developmental biology · 2021Article
- A shared genetic contribution to breast cancer and schizophrenia.Nature communications · 2020Article
- Discovery of shared genomic loci using the conditional false discovery rate approach.Human genetics · 2020Review
- Highly Recurrent Copy Number Variations inFrontiers in psychiatry · 2020Article
- The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges.Psychiatric genetics · 2019Review
- Shared Genetics of Psychiatric Disorders.F1000Research · 2019Review
- Prediction of smoking by multiplex bisulfite PCR with long amplicons considering allele-specific effects on DNA methylation.Clinical epigenetics · 2018Article
- INFERNO: inferring the molecular mechanisms of noncoding genetic variants.Nucleic acids research · 2018Article
- Enrichment of genetic markers of recent human evolution in educational and cognitive traits.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 5 countries.
Funding
Abstract
Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there is a shared genetic architecture between schizophrenia and cancer, with the aim to identify specific overlapping genetic loci. First, we performed genome-wide enrichment analysis and second, we analyzed specific loci jointly associated with schizophrenia and cancer by the conjunction false discovery rate. We analyzed the largest genome-wide association studies of schizophrenia and lung, breast, prostate, ovary, and colon-rectum cancer including more than 220,000 subjects, and included genetic association with smoking behavior. Polygenic enrichment of associations with lung cancer was observed in schizophrenia, and weak enrichment for the remaining cancer sites. After excluding the major histocompatibility complex region, we identified three independent loci jointly associated with schizophrenia and lung cancer. The strongest association included nicotinic acetylcholine receptors and is an established pleiotropic locus shared between lung cancer and smoking. The two other loci were independent of genetic association with smoking. Functional analysis identified downstream pleiotropic effects on epigenetics and gene-expression in lung and brain tissue. These findings suggest that genetic factors may explain partly the observed epidemiological association of lung cancer and schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.