ArticleNature communications2018
Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.
Open access · goldAbstract readEvaluation Study
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
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0cells of the map it votes in
156citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
156 citing papers in PubMed, 322 citations in OpenAlex.
- Detection of mutant cancer-derived circRNAs in extracellular vesicles by rolling circle amplification.Molecular therapy. Nucleic acids · 2026Article
- How is Nanoarchitectonics Shaping Extracellular Vesicle Research?Advanced healthcare materials · 2026Review
- Circadian control of circulating tumour-derived extracellular vesicle secretion affects targeted therapy efficacy.Nature cell biology · 2026Article
- Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer-Associated Protein Signatures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Bioinspired Three-Dimensional High-Curvature Nano-Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning-Assisted Prostate Cancer Precision Diagnosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer's disease.Nature communications · 2026Article
- Acoustic separation and isolation of viruses, small extracellular vesicles and other nanoscale bioparticles.Nature protocols · 2026Review
- Optimization of Microfluidic Geometry for Extracellular Vesicle Capture Using an Automated Parallel Pattern Search.Proteomics · 2026Article
- From cell lines to the clinic: identifying a urinary BlCa-EV signature through comparative proteomics of bladder cancer lysates and extracellular vesicles.Cell communication and signaling : CCS · 2026Article
- Microfluidic approaches for liquid biopsy in glioblastoma: Insights into diagnostic and follow-up strategies.Bioengineering & translational medicine · 2026Review
- Spatiotemporal Confinements of Distance-Dependent Emitters for Enhancing Plasmonic Signals.ACS applied materials & interfaces · 2026Article
- Emerging liquid biopsy tools to analyse cancer biomarkers: electrochemical sensors and extracellular vesicle analysis.Biochemical Society transactions · 2026Review
- Cell Culture Substrate Variation Alters Extracellular Vesicle Biogenesis Without Affecting Non-Coding Repeat RNA Profile.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- From biogenesis to host modulation: the expanding biology of oral streptococcal membrane vesicles.FEMS microbiology reviews · 2026Review
- Engineered nanomedicine remodels the postoperative cavity microenvironment to suppress glioblastoma recurrence.Theranostics · 2026Review
- Quantification of EV-associated miRNA in liquid biopsies for biomarker signature development.Extracellular vesicles and circulating nucleic acids · 2026Review
- Engineered exosome biomedical technologies for precision diagnosis and therapy in orthopedic diseases.Frontiers in medicine · 2026Review
- Multi-Omics Evidence Based on Spatial Transcriptomics Data Reveals the Therapeutic Value of Copper Death Genes in Glioblastoma.International journal of genomics · 2026Article
- Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.Nature communications · 2025Article
- Plasma Extracellular Vesicles as Liquid Biopsies for Glioblastoma: Biomarkers, Subpopulation Enrichment, and Clinical Translation.International journal of molecular sciences · 2025Review
96 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 3 countries.
Eduardo ReáteguiCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Kristan E van der VosNeurodiscovery Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.ORCID http://orcid.org/0000-0001-6210-9982
Charles P LaiNeurodiscovery Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
Mahnaz ZeinaliCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Nadia A AtaiNeurodiscovery Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
Berent AldikactiCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Frederick P FloydCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Aimal H KhankhelCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Vishal ThaparMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Fred H HochbergDepartment of Neurosurgery, University of California San Diego, La Jolla, CA, 92093, USA.
Lecia V SequistMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Brian V NahedMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Bob S CarterDepartment of Neurosurgery, University of California San Diego, La Jolla, CA, 92093, USA.
Mehmet TonerCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Leonora BalajNeurodiscovery Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
David T TingMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Xandra O BreakefieldNeurodiscovery Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02124, USA.
Shannon L StottCenter for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA. sstott@mgh.harvard.edu.
Harvard University · USShriners Hospitals for Children - Erie · USUniversity of California San Diego · US
Funding
The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9MBio-MicroElectroMechanical Systems Resource CenterP41EB002503 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET · 2004 to 2018
$17.4MTransfer of microRNA regulators from glioblastoma to brain microenvironment U19CA179563 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, CHAREST, ALAIN · 2013 to 2017
$8.6MThe power of extracellular vesicles in glioblastomaR35CA232103 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS · 2018 to 2024
$6.9MPoint-of-Care Microfluidics in Lung CancerR01EB008047 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET · 2007 to 2009
$3.4MNCI NIH HHS P01 CA069246NCI NIH HHS R35 CA232103NCI NIH HHS U19 CA179563NIBIB NIH HHS P41 EB002503NIBIB NIH HHS R01 EB008047
Abstract
Extracellular vesicles (EVs) carry RNA, DNA, proteins, and lipids. Specifically, tumor-derived EVs have the potential to be utilized as disease-specific biomarkers. However, a lack of methods to isolate tumor-specific EVs has limited their use in clinical settings. Here we report a sensitive analytical microfluidic platform (
Indexed as
Biological TransportBrain NeoplasmsCell Line, TumorErbB ReceptorsExtracellular VesiclesGlioblastomaHumansMicrofluidicsRNAepidermal growth factor receptor VIIIErbB ReceptorsRNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.