ArticleJournal of immunology (Baltimore, Md. : 1950)2018
IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
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Who cites it
33 citing papers in PubMed, 40 citations in OpenAlex.
- IL-4-STAT6 signaling delays protective CD8Nature immunology · 2026Article
- Bridging the gap: Insights in the immunopathology of Lyme borreliosis.European journal of immunology · 2024Review
- Latent microbial infections leading to myelin and axonal damage in multiple sclerosis: A narrative review.Current journal of neurology · 2024Article
- Identification of Major Histocompatibility Complex Class II Epitopes From Lyme Autoantigen Apolipoprotein B-100 and Borrelia burgdorferi Mcp4 in Murine Lyme Arthritis.The Journal of infectious diseases · 2024Article
- Steady-state, therapeutic, and helminth-induced IL-4 compromise protective CD8 T cell bystander activation.bioRxiv : the preprint server for biology · 2024Article
- Mechanisms governing bystander activation of T cells.Frontiers in immunology · 2024Review
- Soluble factors from TLR4- or TCR-activated cells contribute to stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells.Immunologic research · 2023Article
- Memory T cells possess an innate-like function in local protection from mucosal infection.The Journal of clinical investigation · 2023Article
- Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells.The Journal of clinical investigation · 2023Article
- Lyme disease and the pursuit of a clinical cure.Frontiers in medicine · 2023Review
- The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance.PLoS pathogens · 2022Article
- CD4 T cell responses in persistent Borrelia burgdorferi infection.Current opinion in immunology · 2022Review
- A dormant T-cell population with autoimmune potential exhibits low self-reactivity and infiltrates islets in type 1 diabetes.European journal of immunology · 2022Article
- Borrelia burgdorferi Is a Poor Inducer of Gamma Interferon: Amplification Induced by Interleukin-12.Infection and immunity · 2022Article
- Significance of bystander T cell activation in microbial infection.Nature immunology · 2022Review
- Lyme arthritis: linking infection, inflammation and autoimmunity.Nature reviews. Rheumatology · 2021Review
- Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells.JCI insight · 2021Article
- The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Predicting Lyme Disease From Patients' Peripheral Blood Mononuclear Cells Profiled With RNA-Sequencing.Frontiers in immunology · 2021Article
- Immune Response toCurrent issues in molecular biology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Sarah K WhitesideDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.ORCID 0000-0003-4354-4713
Jeremy P SnookDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.ORCID 0000-0002-1396-9254
Ying MaDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.
F Lynn SondereggerDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.
Colleen FisherDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.ORCID 0000-0002-3688-6283
Charisse PetersenDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.ORCID 0000-0003-4045-2610
James F ZacharyDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802.
June L RoundDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.
Matthew A WilliamsDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and.
Janis J WeisDepartment of Pathology, University of Utah, Salt Lake City, UT 84112; and Janis.weis@path.utah.edu.ORCID 0000-0001-7214-5987
University of Utah · USUniversity of Illinois Urbana-Champaign · US
Funding
MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITYR01AR043521 · NIAMS · UNIVERSITY OF UTAH · PI WEIS, JANIS J. · 1994 to 2024
$9.4MBORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITISR01AI032223 · NIAID · UNIVERSITY OF UTAH · PI WEIS, JANIS J. · 1993 to 2023
$7.8MTraining Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0MDeveloping therapies to target the microbiotaDP2AT008746 · NCCIH · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2014 to 2014
$2.2MUniv of Utah Cell Sorter for Flow Cytometry CoreS10RR026802 · NCRR · UNIVERSITY OF UTAH · PI GREEN, WAYNE FRANCIS · 2010 to 2010
$500kExploring the function of a novel, microbiota-regulated gene in T cellsR21AI109122 · NIAID · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2014 to 2015
$410kRole of Zfp318 in the functional development of B cellsR21AI114462 · NIAID · UNIVERSITY OF UTAH · PI WEIS, JANIS J. · 2015 to 2016
$410kThe role of T cell intrinsic TLR signaling on host-commensal interactionsR56AI107090 · NIAID · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2013 to 2013
$350kExploring the mechanisms of T cell intrinsic TLR2 signaling on Treg functionK22AI095375 · NIAID · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2012 to 2013
$270kHIV VACCINE PRODUCTIONN01AI095375 · NIAID · SRI INTERNATIONAL · PI KUNG, ADA P · 1999 to 2000
$61kNCCIH NIH HHS DP2 AT008746NCRR NIH HHS S10 RR026802NIAID NIH HHS K22 AI095375NIAID NIH HHS N01 AI095375NIAID NIH HHS R01 AI032223NIAID NIH HHS R21 AI109122NIAID NIH HHS R21 AI114462NIAID NIH HHS R56 AI107090NIAID NIH HHS T32 AI055434NIAMS NIH HHS R01 AR043521
Abstract
T cells predominate the immune responses in the synovial fluid of patients with persistent Lyme arthritis; however, their role in Lyme disease remains poorly defined. Using a murine model of persistent Lyme arthritis, we observed that bystander activation of CD4
Indexed as
AnimalsFemaleInterleukin-10Lyme DiseaseLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, TransgenicT-LymphocytesToll-Like Receptor 2IL10 protein, mouseInterleukin-10Tlr2 protein, mouseToll-Like Receptor 2
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.