Evidence map›Paper›PMID 29330297›Full record

ArticleMolecular cancer research : MCR2018

Characterization and Evidence of the miR-888 Cluster as a Novel Cancer Network in Prostate.

Tsuyoshi Hasegawa, Garrison J Glavich, Mary Pahuski, Aleena Short, O John Semmes, Lifang Yang, Vitold Galkin, Richard Drake, Aurora Esquela-Kerscher

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  5. Exploring the Therapeutic Potential ofInternational journal of molecular sciences · 2023
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  14. ChrXq27.3 miRNA cluster functions in cancer development.Journal of experimental & clinical cancer research : CR · 2021
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tsuyoshi HasegawaDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
Garrison J GlavichDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
Mary PahuskiDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
Aleena ShortDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
O John SemmesDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
Lifang YangDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia.
Vitold GalkinDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia.
Richard DrakeDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina.
Aurora Esquela-KerscherDepartment of Microbiology & Molecular Cell Biology, Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia. kerschae@evms.edu.
Eastern Virginia Medical School · USMedical University of South Carolina · US

Funding

Development of Protein Biomarkers in Post-DRE Urine for use in Liquid Biopsy of Prostate CancerU01CA214194 · NCI · EASTERN VIRGINIA MEDICAL SCHOOL · PI BOUTROS, PAUL CHRISTOPHER, KISLINGER, THOMAS · 2016 to 2021
$2.5M
Role of the EPS Urine-Derived MicroRNA miR-888 in Prostate Cancer ProgressionR21CA175894 · NCI · EASTERN VIRGINIA MEDICAL SCHOOL · PI KERSCHER, AURORA ESQUELA · 2014 to 2015
$363k
NCI NIH HHS R21 CA175894NCI NIH HHS U01 CA214194
6 · The paper itself

Abstract

Prostate cancer afflicts 1 in 7 men and is the second leading cause of male cancer-related deaths in the United States. MicroRNAs (miRNAs), an extensive class of approximately 22 nucleotide noncoding RNAs, are often aberrantly expressed in tissues and fluids from prostate cancer patients, but the mechanisms of how specific miRNAs regulate prostate tumorigenesis and metastasis are poorly understood. Here, miR-888 was identified as a novel prostate factor that promotes proliferation and migration. miR-888 resides within a genomic cluster of 7 miRNA genes (

Indexed as

Gene Regulatory NetworksAnimalsBiomarkers, TumorCell MovementCell ProliferationChromosome MappingExosomesGene Expression Regulation, NeoplasticHumansMaleMiceMicroRNAsMultigene FamilyNeoplasm TransplantationPC-3 CellsProstatic NeoplasmsBiomarkers, TumorMicroRNAsMIRN888 microRNA, humanMIRN892 microRNA, human

Identifiers

PMID29330297
PMCPMC5882523
OpenAlexW2782716520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.