ArticleAmerican journal of ophthalmology2018
Fundus Densitometry Findings Suggest Optic Disc Hemorrhages in Primary Open-Angle Glaucoma Have an Arterial Origin.
Article in American journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The impact of disc hemorrhage studies on our understanding of glaucoma: a systematic review 50 years after the rediscovery of disc hemorrhage.Japanese journal of ophthalmology · 2019Pooled it
- Multiple cytokine analysis of aqueous humor in uveitis with or without secondary glaucoma.BMC ophthalmology · 2024Article
- Disc Hemorrhages in Open-Angle Glaucoma-Between a Rock and a Hard Place?JAMA ophthalmology · 2024Article
- Super-Resolution Ultrasound Localization Microscopy for Visualization of the Ocular Blood Flow.IEEE transactions on bio-medical engineering · 2022Article
- Characterization of Prelaminar Wedge-Shaped Defects in Primary Open-Angle Glaucoma.Current eye research · 2021Article
- Early localized alterations of the retinal inner plexiform layer in association with visual field worsening in glaucoma patients.PloS one · 2021Article
- Densitometric Profiles of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study.American journal of ophthalmology · 2020Article
- Disc Hemorrhages Are Associated With the Presence and Progression of Glaucomatous Central Visual Field Defects.Journal of glaucoma · 2020Observational
- Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans.Scientific reports · 2018Article
- Embedded deep learning in ophthalmology: making ophthalmic imaging smarter.Therapeutic advances in ophthalmologyReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo analyze optic disc hemorrhages (DH) associated with primary open-angle glaucoma by quantifying their geometric profile and comparing their densitometry with hemorrhages from retinal vein occlusions (RVO) and retinal macroaneurysms (MA), which have venous and arterial sources of bleeding, respectively.
designRetrospective cross-sectional study.
methodsSetting: Massachusetts Eye & Ear. POPULATION: Fundus images of DH (n = 40), MA (n = 14), and RVO (n = 25) were identified. Patient clinical backgrounds and demographics were obtained.
main outcome measuresGrayscale pixel intensity units of hemorrhages and adjacent arteriole and venule over the same background tissue were measured. Densitometry differentials (arteriole or venule minus hemorrhage [ΔA and ΔV, respectively]) were calculated. The ratios of length (radial) to midpoint width for DH were calculated. Mean ΔA and ΔV between groups were compared with t tests. Multiple linear regression assessed the relation of retinal hemorrhage diagnosis to ΔA and ΔV and of DH shape to ΔA and ΔV.
resultsMean (± standard deviation) ΔA and ΔV for DH (6.9 ± 7.1 and -4.7 ± 8.0 pixel intensity units, respectively) and MA (5.3 ± 5.9 and -6.0 ± 4.6, respectively) were comparable (P ≥ .43). Mean ΔA (14.6 ± 7.7) and ΔV (6.4 ± 6.3) for RVO were significantly higher compared to DH and MA (P < .0001) and remained significant in multivariable analyses. A unit increase in DH length-to-width ratio was associated with 1.2 (0.5) and 1.3 (0.5) pixel intensity unit (standard error) decrease in ΔA and ΔV, respectively (P ≤ .014).
conclusionsDH have densitometry profiles comparable to MA and different from RVO, suggesting that DH in glaucoma have an arterial origin.
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