ReviewInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2019
Lost connections: Oxytocin and the neural, physiological, and behavioral consequences of disrupted relationships.
Review in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Grief-Related Psychopathology from Complicated Grief to DSM-5-TR Prolonged Grief Disorder: A Systematic Review of Biochemical Findings.International journal of molecular sciences · 2025Pooled it
- Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration.Human brain mapping · 2023Trial
- Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder.Journal of neurochemistry · 2026Review
- Functional significance of some common oxytocin receptor SNPs involved in complex human traits.BMC molecular and cell biology · 2025Article
- Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner.Annals of the New York Academy of Sciences · 2024Review
- Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers' brain and stress-coping behavior in the first week postpartum.Neuroscience applied · 2024Article
- Neurobiology and treatment advances for prolonged grief disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus.BMC genomics · 2023Article
- Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023Review
- Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (Microtus ochrogaster).Molecular and cellular endocrinology · 2023Article
- Review
- Article
- Microbiome and Metabolome Variation as Indicator of Social Stress in Female Prairie Voles.International journal of molecular sciences · 2023Article
- Measurement of interpersonal physiological synchrony in dyads: A review of timing parameters used in the literature.Cognitive, affective & behavioral neuroscience · 2022Review
- Sex, love and oxytocin: Two metaphors and a molecule.Neuroscience and biobehavioral reviews · 2022Review
- Oxytocin receptors are widely distributed in the prairie vole (Microtus ochrogaster) brain: Relation to social behavior, genetic polymorphisms, and the dopamine system.The Journal of comparative neurology · 2022Article
- Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities.Endocrinology · 2022Review
- Oxytocin and oxygen: the evolution of a solution to the 'stress of life'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Interactions between thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Risk-Taking Behavior among Suicide Attempters.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In humans and rodent animal models, the brain oxytocin system is paramount for facilitating social bonds, from the formation and consequences of early-life parent-infant bonds to adult pair bond relationships. In social species, oxytocin also mediates the positive effects of healthy social bonds on the partners' well-being. However, new evidence suggests that the negative consequences of early neglect or partner loss may be mediated by disruptions in the oxytocin system as well. With a focus on oxytocin and its receptor, we review studies from humans and animal models, i.e. mainly from the biparental, socially monogamous prairie vole (Microtus ochrogaster), on the beneficial effects of positive social relationships both between offspring and parents and in adult partners. The abundance of social bonds and benevolent social relationships, in general, are associated with protective effects against psycho- and physiopathology not only in the developing infant, but also during adulthood. Furthermore, we discuss the negative effects on well-being, emotionality and behavior, when these bonds are diminished in quality or are disrupted, for example through parental neglect of the young or the loss of the partner in adulthood. Strikingly, in prairie voles, oxytocinergic signaling plays an important developmental role in the ability to form bonds later in life in the face of early-life neglect, while disruption of oxytocin signaling following partner loss results in the emergence of depressive-like behavior and physiology. This review demonstrates the translational value of animal models for investigating the oxytocinergic mechanisms that underlie the detrimental effects of developmental parental neglect and pair bond disruption, encouraging future translationally relevant studies on this topic that is so central to our daily lives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.