ArticleAmerican journal of infection control2018
A multistate investigation of health care-associated Burkholderia cepacia complex infections related to liquid docusate sodium contamination, January-October 2016.
Article in American journal of infection control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A Nosocomial Outbreak ofAntibiotics (Basel, Switzerland) · 2025Article
- Microbiological Contamination of Medicinal Products -Is It a Significant Problem?Pharmaceuticals (Basel, Switzerland) · 2025Review
- Challenges and mitigation strategies associated with Burkholderia cepacia complex contamination in pharmaceutical manufacturing.Archives of microbiology · 2024Review
- Carbapenem-ResistantTransboundary and emerging diseases · 2024Article
- Article
- An outbreak ofInfection control and hospital epidemiology · 2023Article
- Article
- Framing Bacterial Genomics for Public Health (Care).Journal of clinical microbiology · 2021Article
- Neonatal sepsis in Sana'a city, Yemen: a predominance of Burkholderia cepacia.BMC infectious diseases · 2021Article
- Evolution towards Virulence in amBio · 2021Article
- Distribution of Burkholderia cepacia complex species isolated from industrial processes and contaminated products in Argentina.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Clinical course, treatment and visual outcome of an outbreak of Burkholderia contaminans endophthalmitis following cataract surgery.Journal of ophthalmic inflammation and infection · 2021Article
- Polyclonal Burkholderia cepacia Complex Outbreak in Peritoneal Dialysis Patients Caused by Contaminated Aqueous Chlorhexidine.Emerging infectious diseases · 2020Article
- Regulation of Virulence by Two-Component Systems in PathogenicInfection and immunity · 2020Review
- Review
- Article
- Multistate Outbreak of Burkholderia cepacia Complex Bloodstream Infections After Exposure to Contaminated Saline Flush Syringes: United States, 2016-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Investigation of healthcare infection risks from water-related organisms: Summary of CDC consultations, 2014-2017.Infection control and hospital epidemiology · 2019Observational
- Outbreak ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundOutbreaks of health care-associated infections (HAIs) caused by Burkholderia cepacia complex (Bcc) have been associated with medical devices and water-based products. Water is the most common raw ingredient in nonsterile liquid drugs, and the significance of organisms recovered from microbiologic testing during manufacturing is assessed using a risk-based approach. This incident demonstrates that lapses in manufacturing practices and quality control of nonsterile liquid drugs can have serious unintended consequences.
methodsAn epidemiologic and laboratory investigation of clusters of Bcc HAIs that occurred among critically ill, hospitalized, adult and pediatric patients was performed between January 1, 2016, and October 31, 2016.
resultsOne hundred and eight case patients with Bcc infections at a variety of body sites were identified in 12 states. Two distinct strains of Bcc were obtained from patient clinical cultures. These strains were found to be indistinguishable or closely related to 2 strains of Bcc obtained from cultures of water used in the production of liquid docusate, and product that had been released to the market by manufacturer X.
conclusionsThis investigation highlights the ability of bacteria present in nonsterile, liquid drugs to cause infections or colonization among susceptible patients. Prompt reporting and thorough investigation of potentially related infections may assist public health officials in identifying and removing contaminated products from the market when lapses in manufacturing occur.
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