Evidence map›Paper›PMID 29329682›Full record

ArticleVirology2018

Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function.

Javier A Jaimes, Gary R Whittaker

Abstract read
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 130 citations in OpenAlex.

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  20. Antiviral activity ofThe veterinary quarterly · 2024
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Javier A JaimesDepartment of Microbiology, College of Agricultural and Life Sciences, Cornell University, 930 Campus Rd. VMC C4-133, Ithaca, NY 14853, USA. Electronic address: jaj246@cornell.edu.
Gary R WhittakerDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, VMC C4-127, Ithaca, NY 14853, USA. Electronic address: grw7@cornell.edu.
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline coronavirus (FCoV) is an etiological agent that causes a benign enteric illness and the fatal systemic disease feline infectious peritonitis (FIP). The FCoV spike (S) protein is considered the viral regulator for binding and entry to the cell. This protein is also involved in FCoV tropism and virulence, as well as in the switch from enteric disease to FIP. This regulation is carried out by spike's major functions: receptor binding and virus-cell membrane fusion. In this review, we address important aspects in FCoV genetics, replication and pathogenesis, focusing on the role of S. To better understand this, FCoV S protein models were constructed, based on the human coronavirus NL63 (HCoV-NL63) S structure. We describe the specific structural characteristics of the FCoV S, in comparison with other coronavirus spikes. We also revise the biochemical events needed for FCoV S activation and its relation to the structural features of the protein.

Indexed as

AnimalsCatsCoronavirus, FelineFeline Infectious PeritonitisGene Expression Regulation, ViralSpike Glycoprotein, CoronavirusVirus ReplicationSpike Glycoprotein, Coronavirusspike protein, feline infectious peritonitis virusCleavage activationCoronavirusFeline coronavirusFeline infectious peritonitisPathogenesisSerotypeSpike proteinSpike structureTropism

Identifiers

PMID29329682
PMCPMC7112122
OpenAlexW2783375886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.