ArticleBMC cancer2018
Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Learning curve of laparoscopic and robotic total gastrectomy: A systematic review and meta-analysis.Surgery today · 2024Pooled it
- Trial
- Prognostic impact of regional lymph node excision in T3-4N+M0 gastric cancer: a retrospective cohort study on nomogram development and external validation in China.International journal of surgery (London, England) · 2026Article
- Article
- Examining more than 35 lymph nodes improves the staging and survival in resectable advanced gastric cancer: a multi-institutional study in China.Surgery today · 2025Observational
- R1 Resection in Gastric Cancer: Marker of Tumor Biology Rather Than Surgical Failure.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Evaluating the impact of a navigation system on the initial cases of robotic gastrectomy for gastric cancer.Journal of robotic surgery · 2025Article
- Survival Outcomes Between Minimally Invasive and Open Gastrectomy in Early and Locally Advanced Gastric Adenocarcinoma in a Western Center.Journal of gastrointestinal cancer · 2025Article
- The impact of the number of lymph nodes removed with D2 lymph node dissection on survival in gastric cancer.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Development and validation of a Log odds of negative lymph nodes/T stage ratio-based prognostic model for gastric cancer.Frontiers in oncology · 2025Article
- Construction of a modified TNM staging system and prediction model based on examined lymph node counts for gastric cancer patients at pathological stage N3.Frontiers in oncology · 2025Article
- Distribution of Perigastric Station 4d Lymph Nodes in Vascularized Gastroepiploic Lymph Node Transfer: An Anatomic Study and Case Series.Annals of surgical oncology · 2024Article
- Real-world Nationwide Outcomes of Minimally Invasive Surgery for Advanced Gastric Cancer Based on Korean Gastric Cancer Association-Led Survey.Journal of gastric cancer · 2024Article
- Impact of Removal of Lymph Nodes on Survival in Stage I-III Gastric Signet-Ring Cell Cancer: The More, the Better?Annals of surgical oncology · 2024Article
- Esophagojejunostomy using a circular stapler vs. a linear stapler for gastric cardia cancer patients: impact of upper margin length and tumor size on the survival rate.Frontiers in surgery · 2024Article
- Article
- Subserosal Indocyanine Green Plus Submucosal Carbon Nanoparticle Navigated Laparoscopic Gastrectomy (DANCE-01): a Cohort Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Evaluation of the prognostic value of negative to positive lymph node ratio in gastric cancer: results from multi-institutional cohorts from western and eastern datasets - Cohort study.Annals of medicine and surgery (2012) · 2023Article
- Article
- Short-term outcomes of reduced-port laparoscopic surgery versus conventional laparoscopic surgery for total gastrectomy: a single-institute experience.BMC surgery · 2023Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundGreater lymph node retrieval in gastric cancer improves staging accuracy and may improve survival from increased clearance of nodal micrometastasis. This retrospective cohort study investigated if more lymph nodes removed in gastric cancer increases survival and if such effect is stage-specific due to differential risks of nodal micrometastasis and systemic disease.
methodsThe prospectively collected database of curatively resected gastric cancer patients in National Cancer Center, South Korea between 2000 and 2009 was reviewed. Disease-free survival (DFS) and overall survival (OS) for all patients and for each stage according to number of lymph nodes examined (1-30, 31-45, > 45) were analyzed.
resultsOf 4049 patients, 96.6% and 98.4% underwent D2 (perigastric and extragastric) lymphadenectomy and had ≥ 15 lymph nodes examined. Mean number of nodes examined was 43. Five-year OS & DFS rates were 83.3% and 80.7%. Patients with > 45 nodes examined had significantly lower DFS (p = 0.002) and OS (p = 0.007) compared to those with 1-30 and 31-45 nodes. However, proportion of patients with > 45 nodes examined increased with stage (p = 0.0005). Per stage, there was no significant difference in DFS and OS according to number of nodes examined except for stage IIIA favoring more nodes (p = 0.018 and p = 0.044, respectively). Similar trend was seen in stage IIB. Number of examined nodes positively correlated with number of pathologic nodes for all patients (r = 0.144, p < .001) but not for stage IIB and IIIA. Number of nodes examined was a significant survival predictor in stage IIIA.
conclusionGreater lymph node harvest showed improved survival in intermediate-stage gastric cancer.
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