ArticleHead & face medicine2018
Granular cell tumors of the tongue: fibroma or schwannoma.
Article in Head & face medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Granular cell tumor mimicking breast carcinoma in a 49-year-old female: a case report.Frontiers in medicine · 2026Article
- Perineural Invasion Exhibits Traits of Neurodegeneration.Journal of dental research · 2025Article
- A Granular Cell Tumor Arising in a Patient with Long-segment Barrett's Esophagus.Internal medicine (Tokyo, Japan) · 2025Article
- Oral granular cell tumor: a collaborative clinicopathological study of 61 cases.Oral and maxillofacial surgery · 2024Article
- Investigation of the Molecular Profile of Granular Cell Tumours and Schwannomas of the Oral Cavity.Dentistry journal · 2022Article
- A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser.Healthcare (Basel, Switzerland) · 2020Article
- Rare case of cartilaginous choristoma of the tongue: case report.Revista cientifica odontologica (Universidad Cientifica del Sur)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGranular cell tumors are benign lesions that typically occur in the oral cavity, but can also be found in other sites. However, the characteristics of these tumors are unclear. Thus, the present study aimed to investigate the immunohistological characteristics of these tumors of the tongue.
methodsSeven patients were treated for granular cell tumors of the tongue at our institution during 2003-2017. Paraffin-embedded specimens were available for all cases; thus, retrospective immunohistochemical analyses were performed.
resultsAll cases exhibited cytoplasmic acidophilic granules in the muscle layer of the tumor. Both the normal nerve cells and tumor cells also stained positive for PGP9.5, NSE, calretinin, and GFAP. A nucleus of tumor cells was typically present in the margin. The PAS-positive granules were also positive for CD68 (a lysozyme glycoprotein marker). Various sizes of nerve fibers were observed in each tumor, and granular cells were observed in the nerve fibers of a representative case.
conclusionsBased on our immunohistological findings, granular cell tumors may be derived from Schwann cells, and the presence of CD68 indicates that Wallerian degeneration after nerve injury may be a contributor to tumor formation. Thus, a safe surgical margin is needed to detect the infiltrative growth of granular cell tumors.
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