Evidence map›Paper›PMID 29329455›Full record

ArticleThe Journal of infectious diseases2018

Serologic Evidence of Ebolavirus Infection in a Population With No History of Outbreaks in the Democratic Republic of the Congo.

Sabue Mulangu, Vivian H Alfonso, Nicole A Hoff, Reena H Doshi, Prime Mulembakani, Neville K Kisalu, Emile Okitolonda-Wemakoy, Benoit Ilunga Kebela, Hadar Marcus, Joseph Shiloach and 5 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Sabue MulanguNational Institute of Allergy and Infectious Diseases, Vaccine Research Center, Bethesda, Maryland.
Vivian H AlfonsoUCLA Fielding School of Public Health, Los Angeles, California.
Nicole A HoffUCLA Fielding School of Public Health, Los Angeles, California.
Reena H DoshiUCLA Fielding School of Public Health, Los Angeles, California.
Prime MulembakaniKinshasa School of Public Health.
Neville K KisaluNational Institute of Allergy and Infectious Diseases, Vaccine Research Center, Bethesda, Maryland.
Emile Okitolonda-WemakoyKinshasa School of Public Health.
Benoit Ilunga KebelaDivision de la Lutte Contre les Maladies, Ministere de la Santé, Kinshasa, Democratic Republic of the Congo.
Hadar MarcusNational Institute of Allergy and Infectious Diseases, Vaccine Research Center, Bethesda, Maryland.
Joseph ShiloachBiotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland.
Je-Nie PhueBiotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland.
Linda L WrightNational Institute of Child Health and Human Development, Bethesda, Maryland.
Jean-Jacques Muyembe-TamfumInstitut National de Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo.
Nancy J SullivanNational Institute of Allergy and Infectious Diseases, Vaccine Research Center, Bethesda, Maryland.
Anne W RimoinUCLA Fielding School of Public Health, Los Angeles, California.

Funding

Production and purification of biological compoundsZICDK015500 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SHILOACH, JOSEPH · 2009 to 2022
$7.2M
Emergence of Human Monkeypox in Central AfricaK01AI074810 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RIMOIN, ANNE WALSH · 2008 to 2012
$609k
NIAID NIH HHS K01 AI074810
6 · The paper itself

Abstract

Background: Previous studies suggest that cases of Ebola virus disease (EVD) may go unreported because they are asymptomatic or unrecognized, but evidence is limited by study designs and sample size. Methods: A large population-based survey was conducted (n = 3415) to assess animal exposures and behaviors associated with Ebolavirus antibody prevalence in rural Kasai Oriental province of the Democratic Republic of Congo (DRC). Fourteen villages were randomly selected and all healthy individuals ≥1 year of age were eligible. Results: Overall, 11% of subjects tested positive for Zaire Ebolavirus (EBOV) immunoglobulin G antibodies. Odds of seropositivity were higher for study participants older than 15 years of age and for males. Those residing in Kole (closer to the outbreak site) tested positive at a rate 1.6× higher than Lomela, with seropositivity peaking at a site located between Kole and Lomela. Multivariate analyses of behaviors and animal exposures showed that visits to the forest or hunting and exposure to rodents or duikers predicted a higher likelihood of EBOV seropositivity. Conclusions: These results provide serologic evidence of Ebolavirus exposure in a population residing in non-EBOV outbreak locations in the DRC and define statistically significant activities and animal exposures that associate with EBOV seropositivity.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsAntibodies, ViralBehaviorChildChild, PreschoolDemocratic Republic of the CongoEbolavirusEnvironmental ExposureFemaleGeographyHealthy VolunteersHemorrhagic Fever, EbolaAntibodies, ViralImmunoglobulin GDemocratic Republic of the CongoEbolavirusEbola virus diseaseserologyseroprevalence

Identifiers

PMID29329455
PMCPMC5853806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.