ArticleJournal of experimental botany2018
Brassinosteroids regulate pavement cell growth by mediating BIN2-induced microtubule stabilization.
Article in Journal of experimental botany, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 89 citations in OpenAlex.
- Plant Metabolites Screening Identifies 7-epi-10-Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Arabidopsis microtubule-BRI1-associated proteins negatively regulate hypocotyl elongation by controlling brassinosteroid-dependent cortical microtubule reorientation.Plant communications · 2026Article
- Mapping the Phosphorylation Regulatory Network of Single-Celled Fibre Elongation Mediated by GhBIN2 in Cotton.Plant biotechnology journal · 2025Article
- Brassinosteroids in Cucurbits: Modulators of Plant Growth Architecture and Stress Response.International journal of molecular sciences · 2025Review
- Noninvasive prediction of fetal growth restriction using maternal plasma cell-free RNA: a case-control study.BMC pregnancy and childbirth · 2025Article
- The maize GSK3-like kinase ZmSK1 negatively regulates drought tolerance by phosphorylating the transcription factor ZmCPP2.The Plant cell · 2025Article
- Molecular mechanisms underlying the negative effects of transient heatwaves on crop fertility.Plant communications · 2024Review
- Hierarchical global and local auxin signals coordinate cellular interdigitation inbioRxiv : the preprint server for biology · 2024Article
- The cell surface is the place to be for brassinosteroid perception and responses.Nature plants · 2024Review
- StBIN2 Positively Regulates Potato Formation through Hormone and Sugar Signaling.International journal of molecular sciences · 2023Article
- Microtubule Regulation in Plants: From Morphological Development to Stress Adaptation.Biomolecules · 2023Review
- Mechano-chemical regulation of complex cell shape formation: Epidermal pavement cells-A case study.Quantitative plant biology · 2023Review
- Brassinolide promotes interaction between chloroplasts and mitochondria during the optimization of photosynthesis by the mitochondrial electron transport chain in mesophyll cell protoplasts ofFrontiers in plant science · 2023Article
- Brassinosteroids promote thermotolerance through releasing BIN2-mediated phosphorylation and suppression of HsfA1 transcription factors in Arabidopsis.Plant communications · 2022Article
- A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Silver Nanoparticles Alter Microtubule Arrangement, Dynamics and Stress Phytohormone Levels.Plants (Basel, Switzerland) · 2022Article
- Cell biology of the leaf epidermis: Fate specification, morphogenesis, and coordination.The Plant cell · 2022Review
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- Brassinosteroids regulate petal spur length in Aquilegia by controlling cell elongation.Annals of botany · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brassinosteroids (BRs), a group of plant steroid hormones, play important roles in regulating plant development. The cytoskeleton also affects key developmental processes and a deficiency in BR biosynthesis or signaling leads to abnormal phenotypes similar to those of microtubule-defective mutants. However, how BRs regulate microtubule and cell morphology remains unknown. Here, using liquid chromatography-tandem mass spectrometry, we identified tubulin proteins that interact with Arabidopsis BRASSINOSTEROID INSENSITIVE2 (BIN2), a negative regulator of BR responses in plants. In vitro and in vivo pull-down assays confirmed that BIN2 interacts with tubulin proteins. High-speed co-sedimentation assays demonstrated that BIN2 also binds microtubules. The Arabidopsis genome also encodes two BIN2 homologs, BIN2-LIKE 1 (BIL1) and BIL2, which function redundantly with BIN2. In the bin2-3 bil1 bil2 triple mutant, cortical microtubules were more sensitive to treatment with the microtubule-disrupting drug oryzalin than in wild-type, whereas in the BIN2 gain-of-function mutant bin2-1, cortical microtubules were insensitive to oryzalin treatment. These results provide important insight into how BR regulates plant pavement cell and leaf growth by mediating the stabilization of microtubules by BIN2.
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