ArticlePloS one2018
Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Detection of Pathogens in the Gut Microbiome Prior to Bloodstream Infection in Children with Acute Myeloid Leukemia or Mature B-Cell Non-Hodgkin Lymphoma.Journal of the Pediatric Infectious Diseases Society · 2026Article
- Microbiome Modulation in Pediatric Leukemia: Impact on Graft-Versus-Host Disease and Treatment Outcomes: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Omnigene-GutAMB Express · 2024Article
- Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children.International journal of molecular sciences · 2024Review
- Effect of Axillary Radiograph Rotation and Medial Scapular Visualization on Glenoid Retroversion Measurement.The archives of bone and joint surgery · 2024Article
- The pros and cons of probiotic use in pediatric oncology patients following treatment for acute lymphoblastic leukemia.Frontiers in pediatrics · 2024Review
- Implications of the microbiome and metabolic intermediaries produced by bacteria in breast cancer.Genetics and molecular biology · 2024Article
- Infections of Tumor Prostheses: An Updated Review on Risk Factors, Microbiology, Diagnosis, and Treatment Strategies.Biology · 2023Review
- Analysis of Intestinal Mycobiota of Patients with Clostridioides difficile Infection among a Prospective Inpatient Cohort.Microbiology spectrum · 2022Article
- Dissemination of carbapenemase-producing Enterobacterales in the community of Rawalpindi, Pakistan.PloS one · 2022Article
- Review
- A Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Study.AIDS research and human retroviruses · 2021Article
- Fecal Mycobiota Combined With Host Immune Factors Distinguish Clostridioides difficile Infection From Asymptomatic Carriage.Gastroenterology · 2021Article
- The microbiome in pediatric oncology.Cancer · 2020Review
- Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota.The Journal of clinical endocrinology and metabolism · 2020Article
- Clinical utility of characterizing intestinal flora in septic kidney injury.Chinese medical journal · 2020Review
- Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice.The Journal of biological chemistry · 2020Article
- Among older adults, age-related changes in the stool microbiome differ by HIV-1 serostatus.EBioMedicine · 2019Article
- Oral vitamin BGut microbes · 2019Article
- The Prenatal Microbiome: A New Player for Human Health.High-throughput · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Bloodstream infections (BSI) and Clostridium difficile infections (CDI) in pediatric oncology/hematology/bone marrow transplant (BMT) populations are associated with significant morbidity and mortality. The objective of this study was to explore possible associations between altered microbiome composition and the occurrence of BSI and CDI in a cohort of pediatric oncology patients. Stool samples were collected from all patients admitted to the pediatric oncology floor from Oct.-Dec. 2012. Bacterial profiles from patient stools were determined by bacterial 16S rRNA gene profiling. Differences in overall microbiome composition were assessed by a permutation-based multivariate analysis of variance test, while differences in the relative abundances of specific taxa were assessed by Kruskal-Wallis tests. At admission, 9 of 42 patients (21%) were colonized with C. difficile, while 6 of 42 (14%) subsequently developed a CDI. Furthermore, 3 patients (7%) previously had a BSI and 6 patients (14%) subsequently developed a BSI. Differences in overall microbiome composition were significantly associated with disease type (p = 0.0086), chemotherapy treatment (p = 0.018), BSI following admission from any cause (p < 0.0001) or suspected gastrointestinal organisms (p = 0.00043). No differences in baseline microbiota were observed between individuals who did or did not subsequently develop C. difficile infection. Additionally, multiple bacterial groups varied significantly between subjects with post-admission BSI compared with no BSI. Our results suggest that differences in gut microbiota not only are associated with type of cancer and chemotherapy, but may also be predictive of subsequent bloodstream infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.