SynthesisPloS one2018
Obesity and abnormal glucose tolerance in offspring of diabetic mothers: A systematic review and meta-analysis.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 6 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Long-term metabolic consequences ofFrontiers in endocrinology · 2026Pooled it
- Exploring the health literacy status of people with hearing impairment: a systematic review.Archives of public health = Archives belges de sante publique · 2023Pooled it
- How Do the Different Types of Maternal Diabetes during Pregnancy Influence Offspring Outcomes?Nutrients · 2022Pooled it
- Caesarean section and obesity in young adult offspring: Update of a systematic review with meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Metabolic Syndrome in Offspring of Parents with Metabolic Syndrome: A Meta-Analysis.Obesity facts · 2021Pooled it
- The association of plasma levels of liver enzymes and risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis of observational studies.Acta diabetologica · 2020Pooled it
- Associations between maternal and offspring glucose metabolism: a 9-year follow-up of a randomised controlled trial.Frontiers in endocrinology · 2023Trial
- Higher maternal weight is related to poorer fetal autonomic function.Journal of developmental origins of health and disease · 2021Trial
- Gestational diabetes mellitus in women increased the risk of neonatal infection via inflammation and autophagy in the placenta.Medicine · 2020Trial
- Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus.Journal of diabetes research · 2019Trial
- Gestational diabetes mellitus and offspring health: A 12-year register-based analysis of specialized health care utilization in Finland.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Prenatal exposure to hyperglycemia and child growth trajectories in the first 3 years of life: a prospective birth cohort.BMC medicine · 2025Article
- Gestational Glucose Intolerance and Risk of Obesity in Childhood and Adolescence.The Journal of clinical endocrinology and metabolism · 2025Article
- Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism.Molecular nutrition & food research · 2025Article
- Dietary glycemic index is associated with overweight and obesity in preschool children: a national cross-sectional study in Lebanon.BMC pediatrics · 2025Article
- Timing and Variability of Maternal Hyperglycemia in Insulin-Dependent Diabetes, Long-Term Effects on Offspring Obesity-The TEAM Study.Pregnancy (Hoboken, N.J.) · 2025Article
- Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.Journal of diabetes investigation · 2025Article
- Metformin and risk of adverse pregnancy outcomes among pregnant women with gestational diabetes in the United Kingdom: A population-based cohort study.Diabetes, obesity & metabolism · 2025Article
- Review
- Impacts of low birthweight on kidney development and intergenerational growth of the offspring.iScience · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRising prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) is an emerging public health issue.
objectivesTo investigate the association of maternal hyperglycemia exposure during pregnancy with obesity and abnormal glucose tolerance in offspring, and the age at occurrence.
methodsWe searched MEDLINE and EMBASE for observational studies on obesity and diabetes in offspring of diabetic mothers (gestational diabetes mellitus (GDM), type 1 diabetes mellitus (T1DM) and T2DM), and those on non-diabetic mothers. We performed fixed effect meta-analysis for all studies except when heterogeneity was detected. The quality of studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS).
resultsTwenty observational studies were included involving a total of 26,509 children. Offspring of GDM mother had higher BMI z-score in childhood (pooled MD: 0.14, 95%CI: 0.04-0.24, seven studies, 21,691children, low quality of evidence). Offspring of T1DM mothers had higher BMI z-score from prepubertal to adolescent (pooled MD: 0.35, 95% CI: 0.13-0.58, three studies, 844 children, low quality of evidence) compared with control. After adjustment for maternal pre-pregnancy BMI, this association remained in offspring of T1DM, but disappeared in those of GDM mothers. Offspring of GDM mother had higher 2-hour plasma glucose from prepubertal to early adulthood (pooled MD: 0.43 mmol/L, 95% CI: 0.18-0.69, five studies, 890 children), while those of T1DM mothers had higher rate of T2DM in 2-5 years old to early adulthood (pooled odds ratio [OR], 6.10: 95% CI: 1.23-30.37, two studies, 448 children, very low quality of evidence) compared with control. As there was only one study with offspring of T2DM mothers, evidence is sparse. LIMITATIONS: Only observational studies were included, with a few adequately adjusted for covariables.
conclusionsExposure to maternal hyperglycemia was associated with offspring obesity and abnormal glucose tolerance especially in offspring of T1DM mothers, but the evidence relies on observational studies with low quality of evidence only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.