ArticlePloS one2018
A computational study of the impact of inhomogeneous internodal lengths on conduction velocity in myelinated neurons.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 39 citations in OpenAlex.
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- Defining True Motor Conduction Block in Chronic Immune-Mediated Demyelinating Neuropathies: A Temporal Dispersion-Based Electrodiagnostic Approach.European journal of neurology · 2025Article
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- Morphological variability may limit single-cell specificity to electric field stimulation.Frontiers in synaptic neuroscience · 2025Article
- Article
- Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study.bioRxiv : the preprint server for biology · 2023Article
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- Effects of non-modifiable risk factors of Alzheimer's disease on intracortical myelin content.Alzheimer's research & therapy · 2022Article
- Biophysical mechanism underlying compensatory preservation of neural synchrony over the adult lifespan.Communications biology · 2022Article
- New wave-type mechanism of saltatory conduction in myelinated axons and micro-saltatory conduction in C fibres.European biophysics journal : EBJ · 2020Article
- Sex Differences in the Effect of Alcohol Drinking on Myelinated Axons in the Anterior Cingulate Cortex of Adolescent Rats.Brain sciences · 2019Article
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2 authors at 1 institution in 1 country.
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Abstract
Age-related decreases in the conduction velocity (CV) of action potentials along myelinated axons have been linked to morphological changes in the myelin sheath. In particular, evidence suggests the presence of segmental demyelination and remyelination of axons. In remyelinated segments, the distance between adjacent nodes of Ranvier is typically shorter, and myelin sheaths are thinner. Both experimental and computational evidence indicates that shortened internodes slows CV. In this computational study, we determine the impact of progressive segmental demyelination and remyelination, modeled by shorter internodes with thinner myelin sheaths interspersed with normal ones, upon the CV. We find that CV progressively decreases as the number of remyelinated segments increases, but this decrease is greater than one would expect from an estimate of the CV based merely upon the number of short and long internodes. We trace the additional suppression of the CV to transitions between long and short internodes. Our study presents an important consideration for the precise modeling of neural circuits with remyelinated neurons.
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